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Geyik, Caner; Ciftci, Mustafa; Demir, Bilal; Guler, Bahar; Ozkaya, A. Burak; Gumus, Z. Pinar; Barlas, F. Baris; Demirkol, Dilek Odaci; Coskunol, Hakan; Timur, Suna; Yagci, Yusuf
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Ciftci, Mustafa</subfield> <subfield code="u">Istanbul Tech Univ, Dept Chem, TR-34469 Istanbul, Turkey</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Demir, Bilal</subfield> <subfield code="u">Ege Univ, Dept Biochem, Fac Sci, TR-35100 Izmir, Turkey</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Guler, Bahar</subfield> <subfield code="u">Ege Univ, Dept Biochem, Fac Sci, TR-35100 Izmir, Turkey</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Ozkaya, A. Burak</subfield> <subfield code="u">Ege Univ, Sch Med, Dept Med Biochem, TR-35100 Izmir, Turkey</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Gumus, Z. Pinar</subfield> <subfield code="u">Ege Univ, Inst Drug Abuse Toxicol & Pharmaceut Sci, TR-35100 Izmir, Turkey</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Barlas, F. Baris</subfield> <subfield code="u">Ege Univ, Dept Biochem, Fac Sci, TR-35100 Izmir, Turkey</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Demirkol, Dilek Odaci</subfield> <subfield code="u">Ege Univ, Dept Biochem, Fac Sci, TR-35100 Izmir, Turkey</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Coskunol, Hakan</subfield> <subfield code="u">Ege Univ, Inst Drug Abuse Toxicol & Pharmaceut Sci, TR-35100 Izmir, Turkey</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Timur, Suna</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Yagci, Yusuf</subfield> <subfield code="u">Istanbul Tech Univ, Dept Chem, TR-34469 Istanbul, Turkey</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="p">POLYMER CHEMISTRY</subfield> <subfield code="v">6</subfield> <subfield code="n">30</subfield> <subfield code="c">5470-5477</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="a">Creative Commons Attribution</subfield> <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.1039/c5py00780a</subfield> <subfield code="2">doi</subfield> </datafield> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Controlled release of anticancer drug Paclitaxel using nano-structured amphiphilic star-hyperbranched block copolymers</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="a">Geyik, Caner</subfield> <subfield code="u">Ege Univ, Inst Drug Abuse Toxicol & Pharmaceut Sci, TR-35100 Izmir, Turkey</subfield> </datafield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:zenodo.org:81657</subfield> <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="2">opendefinition.org</subfield> <subfield code="a">cc-by</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2015-01-01</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="u">https://aperta.ulakbim.gov.trrecord/81657/files/bib-bc6347b6-0bff-42f6-8c47-aa7d617052a9.txt</subfield> <subfield code="z">md5:36bbad76ac02b26684746b912791b6db</subfield> <subfield code="s">294</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <controlfield tag="005">20210316055035.0</controlfield> <controlfield tag="001">81657</controlfield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">publication</subfield> <subfield code="b">article</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a">In the present study, two amphiphilic star-hyperbranched copolymers based on poly(methyl methacrylate)-b-poly(2-hydroxyethyl methacrylate) (PMMA-b-PHEMA), with different hydrophilic PHEMA segment contents (PMMA-b-PHEMA-1, and PMMA-b-PHEMA-2), were synthesized, and their drug loading and release profiles were examined using Paclitaxel (PTX) as a model drug. The drug loading capacities and encapsulation efficiencies were found to be similar in both polymers. The encapsulation efficiencies were found to be prominent at 98% and 98.5% for PMMA-b-PHEMA-1 and PMMA-b-PHEMA-2, respectively. On the other hand, the drug release behaviors varied in favor of the block copolymer comprising shorter PHEMA chains (PMMA-b-PHEMA-1). Additionally, to assess the biological effects of PTX-loaded polymers, human non-small cell lung carcinoma (A549) cells were used. Cell viability and cell cycle analysis showed that both polymers were non-toxic to cells. The cytotoxic effect of PTX-loaded PMMA-b-PHEMA-1 on A 549 cells was greater (66.49% cell viability at 5.0 ng mL(-1) PTX) than that of PMMA-b-PHEMA-2 (72.47% cell viability at 5.0 ng mL(-1) PTX), consistent with the drug release experiments.</subfield> </datafield> </record>
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