1 Ocak 2015 Dergi makalesi Açık Erişim

Geyik, Caner; Ciftci, Mustafa; Demir, Bilal; Guler, Bahar; Ozkaya, A. Burak; Gumus, Z. Pinar; Barlas, F. Baris; Demirkol, Dilek Odaci; Coskunol, Hakan; Timur, Suna; Yagci, Yusuf

Citation Style Language JSON

{
  "DOI": "10.1039/c5py00780a", 
  "abstract": "In the present study, two amphiphilic star-hyperbranched copolymers based on poly(methyl methacrylate)-b-poly(2-hydroxyethyl methacrylate) (PMMA-b-PHEMA), with different hydrophilic PHEMA segment contents (PMMA-b-PHEMA-1, and PMMA-b-PHEMA-2), were synthesized, and their drug loading and release profiles were examined using Paclitaxel (PTX) as a model drug. The drug loading capacities and encapsulation efficiencies were found to be similar in both polymers. The encapsulation efficiencies were found to be prominent at 98% and 98.5% for PMMA-b-PHEMA-1 and PMMA-b-PHEMA-2, respectively. On the other hand, the drug release behaviors varied in favor of the block copolymer comprising shorter PHEMA chains (PMMA-b-PHEMA-1). Additionally, to assess the biological effects of PTX-loaded polymers, human non-small cell lung carcinoma (A549) cells were used. Cell viability and cell cycle analysis showed that both polymers were non-toxic to cells. The cytotoxic effect of PTX-loaded PMMA-b-PHEMA-1 on A 549 cells was greater (66.49% cell viability at 5.0 ng mL(-1) PTX) than that of PMMA-b-PHEMA-2 (72.47% cell viability at 5.0 ng mL(-1) PTX), consistent with the drug release experiments.", 
  "author": [
    {
      "family": "Geyik", 
      "given": " Caner"
    }, 
    {
      "family": "Ciftci", 
      "given": " Mustafa"
    }, 
    {
      "family": "Demir", 
      "given": " Bilal"
    }, 
    {
      "family": "Guler", 
      "given": " Bahar"
    }, 
    {
      "family": "Ozkaya", 
      "given": " A. Burak"
    }, 
    {
      "family": "Gumus", 
      "given": " Z. Pinar"
    }, 
    {
      "family": "Barlas", 
      "given": " F. Baris"
    }, 
    {
      "family": "Demirkol", 
      "given": " Dilek Odaci"
    }, 
    {
      "family": "Coskunol", 
      "given": " Hakan"
    }, 
    {
      "family": "Timur", 
      "given": " Suna"
    }, 
    {
      "family": "Yagci", 
      "given": " Yusuf"
    }
  ], 
  "container_title": "POLYMER CHEMISTRY", 
  "id": "81657", 
  "issue": "30", 
  "issued": {
    "date-parts": [
      [
        2015, 
        1, 
        1
      ]
    ]
  }, 
  "page": "5470-5477", 
  "title": "Controlled release of anticancer drug Paclitaxel using nano-structured amphiphilic star-hyperbranched block copolymers", 
  "type": "article-journal", 
  "volume": "6"
}