1 Ocak 2015 Dergi makalesi Açık Erişim

Geyik, Caner; Ciftci, Mustafa; Demir, Bilal; Guler, Bahar; Ozkaya, A. Burak; Gumus, Z. Pinar; Barlas, F. Baris; Demirkol, Dilek Odaci; Coskunol, Hakan; Timur, Suna; Yagci, Yusuf

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/81657</identifier>
  <creators>
    <creator>
      <creatorName>Geyik, Caner</creatorName>
      <givenName>Caner</givenName>
      <familyName>Geyik</familyName>
      <affiliation>Ege Univ, Inst Drug Abuse Toxicol &amp; Pharmaceut Sci, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ciftci, Mustafa</creatorName>
      <givenName>Mustafa</givenName>
      <familyName>Ciftci</familyName>
      <affiliation>Istanbul Tech Univ, Dept Chem, TR-34469 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Demir, Bilal</creatorName>
      <givenName>Bilal</givenName>
      <familyName>Demir</familyName>
      <affiliation>Ege Univ, Dept Biochem, Fac Sci, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Guler, Bahar</creatorName>
      <givenName>Bahar</givenName>
      <familyName>Guler</familyName>
      <affiliation>Ege Univ, Dept Biochem, Fac Sci, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozkaya, A. Burak</creatorName>
      <givenName>A. Burak</givenName>
      <familyName>Ozkaya</familyName>
      <affiliation>Ege Univ, Sch Med, Dept Med Biochem, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gumus, Z. Pinar</creatorName>
      <givenName>Z. Pinar</givenName>
      <familyName>Gumus</familyName>
      <affiliation>Ege Univ, Inst Drug Abuse Toxicol &amp; Pharmaceut Sci, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Barlas, F. Baris</creatorName>
      <givenName>F. Baris</givenName>
      <familyName>Barlas</familyName>
      <affiliation>Ege Univ, Dept Biochem, Fac Sci, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Demirkol, Dilek Odaci</creatorName>
      <givenName>Dilek Odaci</givenName>
      <familyName>Demirkol</familyName>
      <affiliation>Ege Univ, Dept Biochem, Fac Sci, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Coskunol, Hakan</creatorName>
      <givenName>Hakan</givenName>
      <familyName>Coskunol</familyName>
      <affiliation>Ege Univ, Inst Drug Abuse Toxicol &amp; Pharmaceut Sci, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Timur, Suna</creatorName>
      <givenName>Suna</givenName>
      <familyName>Timur</familyName>
    </creator>
    <creator>
      <creatorName>Yagci, Yusuf</creatorName>
      <givenName>Yusuf</givenName>
      <familyName>Yagci</familyName>
      <affiliation>Istanbul Tech Univ, Dept Chem, TR-34469 Istanbul, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Controlled Release Of Anticancer Drug Paclitaxel Using Nano-Structured Amphiphilic Star-Hyperbranched Block Copolymers</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2015</publicationYear>
  <dates>
    <date dateType="Issued">2015-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/81657</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1039/c5py00780a</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">In the present study, two amphiphilic star-hyperbranched copolymers based on poly(methyl methacrylate)-b-poly(2-hydroxyethyl methacrylate) (PMMA-b-PHEMA), with different hydrophilic PHEMA segment contents (PMMA-b-PHEMA-1, and PMMA-b-PHEMA-2), were synthesized, and their drug loading and release profiles were examined using Paclitaxel (PTX) as a model drug. The drug loading capacities and encapsulation efficiencies were found to be similar in both polymers. The encapsulation efficiencies were found to be prominent at 98% and 98.5% for PMMA-b-PHEMA-1 and PMMA-b-PHEMA-2, respectively. On the other hand, the drug release behaviors varied in favor of the block copolymer comprising shorter PHEMA chains (PMMA-b-PHEMA-1). Additionally, to assess the biological effects of PTX-loaded polymers, human non-small cell lung carcinoma (A549) cells were used. Cell viability and cell cycle analysis showed that both polymers were non-toxic to cells. The cytotoxic effect of PTX-loaded PMMA-b-PHEMA-1 on A 549 cells was greater (66.49% cell viability at 5.0 ng mL(-1) PTX) than that of PMMA-b-PHEMA-2 (72.47% cell viability at 5.0 ng mL(-1) PTX), consistent with the drug release experiments.</description>
  </descriptions>
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