1 Ocak 2015 Dergi makalesi Açık Erişim

Geyik, Caner; Ciftci, Mustafa; Demir, Bilal; Guler, Bahar; Ozkaya, A. Burak; Gumus, Z. Pinar; Barlas, F. Baris; Demirkol, Dilek Odaci; Coskunol, Hakan; Timur, Suna; Yagci, Yusuf

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{
  "@context": "https://schema.org/", 
  "@id": 81657, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Inst Drug Abuse Toxicol & Pharmaceut Sci, TR-35100 Izmir, Turkey", 
      "name": "Geyik, Caner"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Tech Univ, Dept Chem, TR-34469 Istanbul, Turkey", 
      "name": "Ciftci, Mustafa"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Dept Biochem, Fac Sci, TR-35100 Izmir, Turkey", 
      "name": "Demir, Bilal"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Dept Biochem, Fac Sci, TR-35100 Izmir, Turkey", 
      "name": "Guler, Bahar"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Sch Med, Dept Med Biochem, TR-35100 Izmir, Turkey", 
      "name": "Ozkaya, A. Burak"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Inst Drug Abuse Toxicol & Pharmaceut Sci, TR-35100 Izmir, Turkey", 
      "name": "Gumus, Z. Pinar"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Dept Biochem, Fac Sci, TR-35100 Izmir, Turkey", 
      "name": "Barlas, F. Baris"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Dept Biochem, Fac Sci, TR-35100 Izmir, Turkey", 
      "name": "Demirkol, Dilek Odaci"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Inst Drug Abuse Toxicol & Pharmaceut Sci, TR-35100 Izmir, Turkey", 
      "name": "Coskunol, Hakan"
    }, 
    {
      "@type": "Person", 
      "name": "Timur, Suna"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Tech Univ, Dept Chem, TR-34469 Istanbul, Turkey", 
      "name": "Yagci, Yusuf"
    }
  ], 
  "datePublished": "2015-01-01", 
  "description": "In the present study, two amphiphilic star-hyperbranched copolymers based on poly(methyl methacrylate)-b-poly(2-hydroxyethyl methacrylate) (PMMA-b-PHEMA), with different hydrophilic PHEMA segment contents (PMMA-b-PHEMA-1, and PMMA-b-PHEMA-2), were synthesized, and their drug loading and release profiles were examined using Paclitaxel (PTX) as a model drug. The drug loading capacities and encapsulation efficiencies were found to be similar in both polymers. The encapsulation efficiencies were found to be prominent at 98% and 98.5% for PMMA-b-PHEMA-1 and PMMA-b-PHEMA-2, respectively. On the other hand, the drug release behaviors varied in favor of the block copolymer comprising shorter PHEMA chains (PMMA-b-PHEMA-1). Additionally, to assess the biological effects of PTX-loaded polymers, human non-small cell lung carcinoma (A549) cells were used. Cell viability and cell cycle analysis showed that both polymers were non-toxic to cells. The cytotoxic effect of PTX-loaded PMMA-b-PHEMA-1 on A 549 cells was greater (66.49% cell viability at 5.0 ng mL(-1) PTX) than that of PMMA-b-PHEMA-2 (72.47% cell viability at 5.0 ng mL(-1) PTX), consistent with the drug release experiments.", 
  "headline": "Controlled release of anticancer drug Paclitaxel using nano-structured amphiphilic star-hyperbranched block copolymers", 
  "identifier": 81657, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Controlled release of anticancer drug Paclitaxel using nano-structured amphiphilic star-hyperbranched block copolymers", 
  "url": "https://aperta.ulakbim.gov.tr/record/81657"
}