1 Ocak 2015 Dergi makalesi Açık Erişim

Geyik, Caner; Ciftci, Mustafa; Demir, Bilal; Guler, Bahar; Ozkaya, A. Burak; Gumus, Z. Pinar; Barlas, F. Baris; Demirkol, Dilek Odaci; Coskunol, Hakan; Timur, Suna; Yagci, Yusuf

Dublin Core

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  <dc:creator>Geyik, Caner</dc:creator>
  <dc:creator>Ciftci, Mustafa</dc:creator>
  <dc:creator>Demir, Bilal</dc:creator>
  <dc:creator>Guler, Bahar</dc:creator>
  <dc:creator>Ozkaya, A. Burak</dc:creator>
  <dc:creator>Gumus, Z. Pinar</dc:creator>
  <dc:creator>Barlas, F. Baris</dc:creator>
  <dc:creator>Demirkol, Dilek Odaci</dc:creator>
  <dc:creator>Coskunol, Hakan</dc:creator>
  <dc:creator>Timur, Suna</dc:creator>
  <dc:creator>Yagci, Yusuf</dc:creator>
  <dc:date>2015-01-01</dc:date>
  <dc:description>In the present study, two amphiphilic star-hyperbranched copolymers based on poly(methyl methacrylate)-b-poly(2-hydroxyethyl methacrylate) (PMMA-b-PHEMA), with different hydrophilic PHEMA segment contents (PMMA-b-PHEMA-1, and PMMA-b-PHEMA-2), were synthesized, and their drug loading and release profiles were examined using Paclitaxel (PTX) as a model drug. The drug loading capacities and encapsulation efficiencies were found to be similar in both polymers. The encapsulation efficiencies were found to be prominent at 98% and 98.5% for PMMA-b-PHEMA-1 and PMMA-b-PHEMA-2, respectively. On the other hand, the drug release behaviors varied in favor of the block copolymer comprising shorter PHEMA chains (PMMA-b-PHEMA-1). Additionally, to assess the biological effects of PTX-loaded polymers, human non-small cell lung carcinoma (A549) cells were used. Cell viability and cell cycle analysis showed that both polymers were non-toxic to cells. The cytotoxic effect of PTX-loaded PMMA-b-PHEMA-1 on A 549 cells was greater (66.49% cell viability at 5.0 ng mL(-1) PTX) than that of PMMA-b-PHEMA-2 (72.47% cell viability at 5.0 ng mL(-1) PTX), consistent with the drug release experiments.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/81657</dc:identifier>
  <dc:identifier>oai:zenodo.org:81657</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>POLYMER CHEMISTRY 6(30) 5470-5477</dc:source>
  <dc:title>Controlled release of anticancer drug Paclitaxel using nano-structured amphiphilic star-hyperbranched block copolymers</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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