1 Ocak 2015 Dergi makalesi Açık Erişim

Geyik, Caner; Ciftci, Mustafa; Demir, Bilal; Guler, Bahar; Ozkaya, A. Burak; Gumus, Z. Pinar; Barlas, F. Baris; Demirkol, Dilek Odaci; Coskunol, Hakan; Timur, Suna; Yagci, Yusuf

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    "creators": [
      {
        "affiliation": "Ege Univ, Inst Drug Abuse Toxicol & Pharmaceut Sci, TR-35100 Izmir, Turkey", 
        "name": "Geyik, Caner"
      }, 
      {
        "affiliation": "Istanbul Tech Univ, Dept Chem, TR-34469 Istanbul, Turkey", 
        "name": "Ciftci, Mustafa"
      }, 
      {
        "affiliation": "Ege Univ, Dept Biochem, Fac Sci, TR-35100 Izmir, Turkey", 
        "name": "Demir, Bilal"
      }, 
      {
        "affiliation": "Ege Univ, Dept Biochem, Fac Sci, TR-35100 Izmir, Turkey", 
        "name": "Guler, Bahar"
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      {
        "affiliation": "Ege Univ, Sch Med, Dept Med Biochem, TR-35100 Izmir, Turkey", 
        "name": "Ozkaya, A. Burak"
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      {
        "affiliation": "Ege Univ, Inst Drug Abuse Toxicol & Pharmaceut Sci, TR-35100 Izmir, Turkey", 
        "name": "Gumus, Z. Pinar"
      }, 
      {
        "affiliation": "Ege Univ, Dept Biochem, Fac Sci, TR-35100 Izmir, Turkey", 
        "name": "Barlas, F. Baris"
      }, 
      {
        "affiliation": "Ege Univ, Dept Biochem, Fac Sci, TR-35100 Izmir, Turkey", 
        "name": "Demirkol, Dilek Odaci"
      }, 
      {
        "affiliation": "Ege Univ, Inst Drug Abuse Toxicol & Pharmaceut Sci, TR-35100 Izmir, Turkey", 
        "name": "Coskunol, Hakan"
      }, 
      {
        "name": "Timur, Suna"
      }, 
      {
        "affiliation": "Istanbul Tech Univ, Dept Chem, TR-34469 Istanbul, Turkey", 
        "name": "Yagci, Yusuf"
      }
    ], 
    "description": "In the present study, two amphiphilic star-hyperbranched copolymers based on poly(methyl methacrylate)-b-poly(2-hydroxyethyl methacrylate) (PMMA-b-PHEMA), with different hydrophilic PHEMA segment contents (PMMA-b-PHEMA-1, and PMMA-b-PHEMA-2), were synthesized, and their drug loading and release profiles were examined using Paclitaxel (PTX) as a model drug. The drug loading capacities and encapsulation efficiencies were found to be similar in both polymers. The encapsulation efficiencies were found to be prominent at 98% and 98.5% for PMMA-b-PHEMA-1 and PMMA-b-PHEMA-2, respectively. On the other hand, the drug release behaviors varied in favor of the block copolymer comprising shorter PHEMA chains (PMMA-b-PHEMA-1). Additionally, to assess the biological effects of PTX-loaded polymers, human non-small cell lung carcinoma (A549) cells were used. Cell viability and cell cycle analysis showed that both polymers were non-toxic to cells. The cytotoxic effect of PTX-loaded PMMA-b-PHEMA-1 on A 549 cells was greater (66.49% cell viability at 5.0 ng mL(-1) PTX) than that of PMMA-b-PHEMA-2 (72.47% cell viability at 5.0 ng mL(-1) PTX), consistent with the drug release experiments.", 
    "doi": "10.1039/c5py00780a", 
    "has_grant": false, 
    "journal": {
      "issue": "30", 
      "pages": "5470-5477", 
      "title": "POLYMER CHEMISTRY", 
      "volume": "6"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2015-01-01", 
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    "resource_type": {
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      "title": "Dergi makalesi", 
      "type": "publication"
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    "title": "Controlled release of anticancer drug Paclitaxel using nano-structured amphiphilic star-hyperbranched block copolymers"
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