5 Aralık 2025 Diğer Açık Erişim

Şirin, Ersin; Sevimli, Esra; Seyhan, Gökçe; Barut, Burak; Kaya, Yunus; Köksoy, Baybars

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">Coumarin</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">triazole</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">enzyme inhibition</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">α-glycosidase</subfield>
  </datafield>
  <datafield tag="041" ind1=" " ind2=" ">
    <subfield code="a">eng</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="o">oai:aperta.ulakbim.gov.tr:286461</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">&lt;p&gt;Novel coumarin-&amp;ndash;triazole-&amp;ndash;coumarin dyads were synthesized and, characterized, and their &amp;alpha;-glycosidase inhibitory activities were evaluated spectrophotometrically. Compound 4e exhibited the most pronounced inhibitory effect, with an IC&lt;sub&gt;50 &lt;/sub&gt;value of 38.98 &amp;plusmn; 0.77 &amp;micro;M. The IC&lt;sub&gt;50&lt;/sub&gt; values for 4d and 4a were 93.55 &amp;plusmn; 1.70 &amp;micro;M and 95.04 &amp;plusmn; 3.55 &amp;micro;M, respectively. The Lineweaver-&amp;ndash;Burk plot showed that 4e&lt;strong&gt; &lt;/strong&gt;inhibited &amp;alpha;-glycosidase in a mixed type. In addition, the &lt;em&gt;K&lt;sub&gt;i&lt;/sub&gt; &lt;/em&gt;value obtained from the Dixon plot was 19.95 &amp;plusmn; 0.15 &amp;mu;M for &amp;alpha;-glycosidase&lt;/p&gt;</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">other</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="a">Creative Commons Attribution-NonCommercial-NoDerivatives</subfield>
    <subfield code="u">https://creativecommons.org/licenses/by-nc-nd/4.0/</subfield>
  </datafield>
  <datafield tag="773" ind1=" " ind2=" ">
    <subfield code="i">isVersionOf</subfield>
    <subfield code="a">10.48623/aperta.286460</subfield>
    <subfield code="n">doi</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="a">Şirin, Ersin</subfield>
    <subfield code="u">Bursa Teknik Üniversitesi</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="z">md5:d617ada871ee4d1352fccc5ef1cd07cc</subfield>
    <subfield code="s">4501866</subfield>
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/286461/files/Supporting Information Revised (1).docx</subfield>
  </datafield>
  <controlfield tag="005">20251205115125.0</controlfield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2025-12-05</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.48623/aperta.286461</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">α-Glycosidase activity of novel coumarin-triazol-coumarin dyads</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="a">cc-by</subfield>
    <subfield code="2">opendefinition.org</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Sevimli, Esra</subfield>
    <subfield code="u">Bursa Teknik Üniversitesi</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Seyhan, Gökçe</subfield>
    <subfield code="u">Karadeniz Teknik Üniversitesi</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Barut, Burak</subfield>
    <subfield code="u">Karadeniz Teknik Üniversitesi</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Kaya, Yunus</subfield>
    <subfield code="u">Bursa Teknik Üniversitesi</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Köksoy, Baybars</subfield>
    <subfield code="u">Bursa Teknik Üniversitesi</subfield>
  </datafield>
  <controlfield tag="001">286461</controlfield>
</record>