5 Aralık 2025 Diğer Açık Erişim

Şirin, Ersin; Sevimli, Esra; Seyhan, Gökçe; Barut, Burak; Kaya, Yunus; Köksoy, Baybars

DataCite XML

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  <identifier identifierType="DOI">10.48623/aperta.286461</identifier>
  <creators>
    <creator>
      <creatorName>Şirin, Ersin</creatorName>
      <givenName>Ersin</givenName>
      <familyName>Şirin</familyName>
      <affiliation>Bursa Teknik Üniversitesi</affiliation>
    </creator>
    <creator>
      <creatorName>Sevimli, Esra</creatorName>
      <givenName>Esra</givenName>
      <familyName>Sevimli</familyName>
      <affiliation>Bursa Teknik Üniversitesi</affiliation>
    </creator>
    <creator>
      <creatorName>Seyhan, Gökçe</creatorName>
      <givenName>Gökçe</givenName>
      <familyName>Seyhan</familyName>
      <affiliation>Karadeniz Teknik Üniversitesi</affiliation>
    </creator>
    <creator>
      <creatorName>Barut, Burak</creatorName>
      <givenName>Burak</givenName>
      <familyName>Barut</familyName>
      <affiliation>Karadeniz Teknik Üniversitesi</affiliation>
    </creator>
    <creator>
      <creatorName>Kaya, Yunus</creatorName>
      <givenName>Yunus</givenName>
      <familyName>Kaya</familyName>
      <affiliation>Bursa Teknik Üniversitesi</affiliation>
    </creator>
    <creator>
      <creatorName>Köksoy, Baybars</creatorName>
      <givenName>Baybars</givenName>
      <familyName>Köksoy</familyName>
      <affiliation>Bursa Teknik Üniversitesi</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Α-Glycosidase Activity Of Novel Coumarin-Triazol-Coumarin Dyads</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2025</publicationYear>
  <subjects>
    <subject>Coumarin</subject>
    <subject>triazole</subject>
    <subject>enzyme inhibition</subject>
    <subject>α-glycosidase</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2025-12-05</date>
  </dates>
  <language>en</language>
  <resourceType resourceTypeGeneral="Other"/>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/286461</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.48623/aperta.286460</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by-nc-nd/4.0/">Creative Commons Attribution-NonCommercial-NoDerivatives</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;Novel coumarin-&amp;ndash;triazole-&amp;ndash;coumarin dyads were synthesized and, characterized, and their &amp;alpha;-glycosidase inhibitory activities were evaluated spectrophotometrically. Compound 4e exhibited the most pronounced inhibitory effect, with an IC&lt;sub&gt;50 &lt;/sub&gt;value of 38.98 &amp;plusmn; 0.77 &amp;micro;M. The IC&lt;sub&gt;50&lt;/sub&gt; values for 4d and 4a were 93.55 &amp;plusmn; 1.70 &amp;micro;M and 95.04 &amp;plusmn; 3.55 &amp;micro;M, respectively. The Lineweaver-&amp;ndash;Burk plot showed that 4e&lt;strong&gt; &lt;/strong&gt;inhibited &amp;alpha;-glycosidase in a mixed type. In addition, the &lt;em&gt;K&lt;sub&gt;i&lt;/sub&gt; &lt;/em&gt;value obtained from the Dixon plot was 19.95 &amp;plusmn; 0.15 &amp;mu;M for &amp;alpha;-glycosidase&lt;/p&gt;</description>
  </descriptions>
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