5 Aralık 2025 Diğer Açık Erişim

Şirin, Ersin; Sevimli, Esra; Seyhan, Gökçe; Barut, Burak; Kaya, Yunus; Köksoy, Baybars

Citation Style Language JSON

{
  "URL": "https://aperta.ulakbim.gov.tr/record/286461", 
  "abstract": "<p>Novel coumarin-&ndash;triazole-&ndash;coumarin dyads were synthesized and, characterized, and their &alpha;-glycosidase inhibitory activities were evaluated spectrophotometrically. Compound 4e exhibited the most pronounced inhibitory effect, with an IC<sub>50 </sub>value of 38.98 &plusmn; 0.77 &micro;M. The IC<sub>50</sub> values for 4d and 4a were 93.55 &plusmn; 1.70 &micro;M and 95.04 &plusmn; 3.55 &micro;M, respectively. The Lineweaver-&ndash;Burk plot showed that 4e<strong> </strong>inhibited &alpha;-glycosidase in a mixed type. In addition, the <em>K<sub>i</sub> </em>value obtained from the Dixon plot was 19.95 &plusmn; 0.15 &mu;M for &alpha;-glycosidase</p>", 
  "author": [
    {
      "family": "\u015eirin", 
      "given": " Ersin"
    }, 
    {
      "family": "Sevimli", 
      "given": " Esra"
    }, 
    {
      "family": "Seyhan", 
      "given": " G\u00f6k\u00e7e"
    }, 
    {
      "family": "Barut", 
      "given": " Burak"
    }, 
    {
      "family": "Kaya", 
      "given": " Yunus"
    }, 
    {
      "family": "K\u00f6ksoy", 
      "given": " Baybars"
    }
  ], 
  "id": "286461", 
  "issued": {
    "date-parts": [
      [
        2025, 
        12, 
        5
      ]
    ]
  }, 
  "language": "eng", 
  "title": "\u03b1-Glycosidase activity of novel coumarin-triazol-coumarin dyads", 
  "type": "article"
}