5 Aralık 2025 Diğer Açık Erişim

Şirin, Ersin; Sevimli, Esra; Seyhan, Gökçe; Barut, Burak; Kaya, Yunus; Köksoy, Baybars

Dublin Core

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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Şirin, Ersin</dc:creator>
  <dc:creator>Sevimli, Esra</dc:creator>
  <dc:creator>Seyhan, Gökçe</dc:creator>
  <dc:creator>Barut, Burak</dc:creator>
  <dc:creator>Kaya, Yunus</dc:creator>
  <dc:creator>Köksoy, Baybars</dc:creator>
  <dc:date>2025-12-05</dc:date>
  <dc:description>Novel coumarin-–triazole-–coumarin dyads were synthesized and, characterized, and their α-glycosidase inhibitory activities were evaluated spectrophotometrically. Compound 4e exhibited the most pronounced inhibitory effect, with an IC50 value of 38.98 ± 0.77 µM. The IC50 values for 4d and 4a were 93.55 ± 1.70 µM and 95.04 ± 3.55 µM, respectively. The Lineweaver-–Burk plot showed that 4e inhibited α-glycosidase in a mixed type. In addition, the Ki value obtained from the Dixon plot was 19.95 ± 0.15 μM for α-glycosidase</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/286461</dc:identifier>
  <dc:identifier>oai:aperta.ulakbim.gov.tr:286461</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>https://creativecommons.org/licenses/by-nc-nd/4.0/</dc:rights>
  <dc:subject>Coumarin</dc:subject>
  <dc:subject>triazole</dc:subject>
  <dc:subject>enzyme inhibition</dc:subject>
  <dc:subject>α-glycosidase</dc:subject>
  <dc:title>α-Glycosidase activity of novel coumarin-triazol-coumarin dyads</dc:title>
  <dc:type>info:eu-repo/semantics/other</dc:type>
  <dc:type>other</dc:type>
</oai_dc:dc>