Diğer Açık Erişim
Şirin, Ersin; Sevimli, Esra; Seyhan, Gökçe; Barut, Burak; Kaya, Yunus; Köksoy, Baybars
Novel coumarin-–triazole-–coumarin dyads were synthesized and, characterized, and their α-glycosidase inhibitory activities were evaluated spectrophotometrically. Compound 4e exhibited the most pronounced inhibitory effect, with an IC50 value of 38.98 ± 0.77 µM. The IC50 values for 4d and 4a were 93.55 ± 1.70 µM and 95.04 ± 3.55 µM, respectively. The Lineweaver-–Burk plot showed that 4e inhibited α-glycosidase in a mixed type. In addition, the Ki value obtained from the Dixon plot was 19.95 ± 0.15 μM for α-glycosidase
| Dosya adı | Boyutu | |
|---|---|---|
|
Supporting Information Revised (1).docx
md5:d617ada871ee4d1352fccc5ef1cd07cc |
4.5 MB | İndir |
| Tüm sürümler | Bu sürüm | |
|---|---|---|
| Görüntülenme | 0 | 0 |
| İndirme | 0 | 0 |
| Veri hacmi | 0 Bytes | 0 Bytes |
| Tekil görüntülenme | 0 | 0 |
| Tekil indirme | 0 | 0 |