5 Aralık 2025 Diğer Açık Erişim

Şirin, Ersin; Sevimli, Esra; Seyhan, Gökçe; Barut, Burak; Kaya, Yunus; Köksoy, Baybars

JSON-LD (schema.org)

{
  "@context": "https://schema.org/", 
  "@id": 286461, 
  "@type": "CreativeWork", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Bursa Teknik \u00dcniversitesi", 
      "name": "\u015eirin, Ersin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bursa Teknik \u00dcniversitesi", 
      "name": "Sevimli, Esra"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Karadeniz Teknik \u00dcniversitesi", 
      "name": "Seyhan, G\u00f6k\u00e7e"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Karadeniz Teknik \u00dcniversitesi", 
      "name": "Barut, Burak"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bursa Teknik \u00dcniversitesi", 
      "name": "Kaya, Yunus"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bursa Teknik \u00dcniversitesi", 
      "name": "K\u00f6ksoy, Baybars"
    }
  ], 
  "datePublished": "2025-12-05", 
  "description": "<p>Novel coumarin-&ndash;triazole-&ndash;coumarin dyads were synthesized and, characterized, and their &alpha;-glycosidase inhibitory activities were evaluated spectrophotometrically. Compound 4e exhibited the most pronounced inhibitory effect, with an IC<sub>50 </sub>value of 38.98 &plusmn; 0.77 &micro;M. The IC<sub>50</sub> values for 4d and 4a were 93.55 &plusmn; 1.70 &micro;M and 95.04 &plusmn; 3.55 &micro;M, respectively. The Lineweaver-&ndash;Burk plot showed that 4e<strong> </strong>inhibited &alpha;-glycosidase in a mixed type. In addition, the <em>K<sub>i</sub> </em>value obtained from the Dixon plot was 19.95 &plusmn; 0.15 &mu;M for &alpha;-glycosidase</p>", 
  "identifier": 286461, 
  "inLanguage": {
    "@type": "Language", 
    "alternateName": "eng", 
    "name": "English"
  }, 
  "keywords": [
    "Coumarin", 
    "triazole", 
    "enzyme inhibition", 
    "\u03b1-glycosidase"
  ], 
  "license": "https://creativecommons.org/licenses/by-nc-nd/4.0/", 
  "name": "\u03b1-Glycosidase activity of novel coumarin-triazol-coumarin dyads", 
  "url": "https://aperta.ulakbim.gov.tr/record/286461"
}