5 Aralık 2025 Diğer Açık Erişim

Şirin, Ersin; Sevimli, Esra; Seyhan, Gökçe; Barut, Burak; Kaya, Yunus; Köksoy, Baybars

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        "affiliation": "Bursa Teknik \u00dcniversitesi", 
        "name": "\u015eirin, Ersin"
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      {
        "affiliation": "Bursa Teknik \u00dcniversitesi", 
        "name": "Sevimli, Esra"
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      {
        "affiliation": "Karadeniz Teknik \u00dcniversitesi", 
        "name": "Seyhan, G\u00f6k\u00e7e"
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        "affiliation": "Karadeniz Teknik \u00dcniversitesi", 
        "name": "Barut, Burak"
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        "name": "Kaya, Yunus"
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        "affiliation": "Bursa Teknik \u00dcniversitesi", 
        "name": "K\u00f6ksoy, Baybars"
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    "description": "<p>Novel coumarin-&ndash;triazole-&ndash;coumarin dyads were synthesized and, characterized, and their &alpha;-glycosidase inhibitory activities were evaluated spectrophotometrically. Compound 4e exhibited the most pronounced inhibitory effect, with an IC<sub>50 </sub>value of 38.98 &plusmn; 0.77 &micro;M. The IC<sub>50</sub> values for 4d and 4a were 93.55 &plusmn; 1.70 &micro;M and 95.04 &plusmn; 3.55 &micro;M, respectively. The Lineweaver-&ndash;Burk plot showed that 4e<strong> </strong>inhibited &alpha;-glycosidase in a mixed type. In addition, the <em>K<sub>i</sub> </em>value obtained from the Dixon plot was 19.95 &plusmn; 0.15 &mu;M for &alpha;-glycosidase</p>", 
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      "triazole", 
      "enzyme inhibition", 
      "\u03b1-glycosidase"
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    "science_branches": [
      "Temel Bilimler > Kimya > Organik Kimya > Heterosiklik Bile\u015fikler Kimyas\u0131", 
      "Temel Bilimler > Kimya > Organik Kimya", 
      "Temel Bilimler > Kimya > Fizikokimya > Hesapsal Kimya"
    ], 
    "title": "\u03b1-Glycosidase activity of novel coumarin-triazol-coumarin dyads"
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