1 Ocak 2012 Dergi makalesi Açık Erişim

Ay, Zuhal Yetkin; Kirzioglu, F. Yesim; Tonguc, Mine Ozturk; Sutcu, Recep; Kapucuoglu, Nilgun

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    <subfield code="a">The presence of leptin (OB) and soluble OB receptor (s-OB-R) in gingival tissue extract and gingival crevicular fluid has led the studies investigating the relationship between OB and periodontal diseases. This study aims to investigate the levels of OB and s-OB-R in serum and their presence in gingiva of healthy controls (HC), gingivitis (G), aggressive periodontitis (AP), and chronic periodontitis (CP) patients; and whether correlations exist between clinical and serum parameters, OB and s-OB-R. Seventy-seven subjects [HC (n = 20), G (n = 20), CP (n = 21), and AP (n = 16)] were included in this study. After the clinical periodontal parameter recordings and venous blood sampling, gingival tissues obtained. Serum parameters' levels determined with enzyme linked immune sorbent assay; and OB and OB-R in gingiva immunohistochemically. No significant differences were observed regarding the serum parameters [high sensitivity C-reactive protein (hs-CRP), lipids, OB, and s-OB-R] when the groups were compared (P &amp;gt; 0.0125). The serum OB has positive correlations with hs-CRP in the G group (P &amp;lt; 0.05), and s-OB-R has presented significant negative correlations with BOP in HC group (P &amp;lt; 0.05), with hs-CRP in G (P &amp;lt; 0.05) and AP groups (P &amp;lt; 0.05). The positive correlations were observed between the serum OB and HDL and body mass index in the CP group (P &amp;lt; 0.05). In all of the tissue samples of all groups, there was positive OB and OB-R immunoreactivity in the gingival epithelium. The gingival tissues contain both OB and OB-R. The serum levels of OB and s-OB-R do not vary between patients and with different periodontal conditions.</subfield>
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    <subfield code="a">Ay, Zuhal Yetkin</subfield>
    <subfield code="u">Suleyman Demirel Univ, Dept Periodontol, Fac Dent, TR-32260 Isparta, Turkey</subfield>
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    <subfield code="a">The gingiva contains leptin and leptin receptor in health and disease</subfield>
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    <subfield code="a">Kirzioglu, F. Yesim</subfield>
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    <subfield code="a">Sutcu, Recep</subfield>
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    <subfield code="a">Kapucuoglu, Nilgun</subfield>
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