1 Ocak 2012 Dergi makalesi Açık Erişim

Ay, Zuhal Yetkin; Kirzioglu, F. Yesim; Tonguc, Mine Ozturk; Sutcu, Recep; Kapucuoglu, Nilgun

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/83713</identifier>
  <creators>
    <creator>
      <creatorName>Ay, Zuhal Yetkin</creatorName>
      <givenName>Zuhal Yetkin</givenName>
      <familyName>Ay</familyName>
      <affiliation>Suleyman Demirel Univ, Dept Periodontol, Fac Dent, TR-32260 Isparta, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kirzioglu, F. Yesim</creatorName>
      <givenName>F. Yesim</givenName>
      <familyName>Kirzioglu</familyName>
      <affiliation>Suleyman Demirel Univ, Dept Periodontol, Fac Dent, TR-32260 Isparta, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tonguc, Mine Ozturk</creatorName>
      <givenName>Mine Ozturk</givenName>
      <familyName>Tonguc</familyName>
      <affiliation>Suleyman Demirel Univ, Dept Periodontol, Fac Dent, TR-32260 Isparta, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sutcu, Recep</creatorName>
      <givenName>Recep</givenName>
      <familyName>Sutcu</familyName>
      <affiliation>Suleyman Demirel Univ, Dept Biochem, Fac Dent, TR-32260 Isparta, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kapucuoglu, Nilgun</creatorName>
      <givenName>Nilgun</givenName>
      <familyName>Kapucuoglu</familyName>
      <affiliation>Suleyman Demirel Univ, Dept Pathol, Fac Dent, TR-32260 Isparta, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>The Gingiva Contains Leptin And Leptin Receptor In Health And Disease</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2012</publicationYear>
  <dates>
    <date dateType="Issued">2012-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/83713</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s10266-011-0043-0</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The presence of leptin (OB) and soluble OB receptor (s-OB-R) in gingival tissue extract and gingival crevicular fluid has led the studies investigating the relationship between OB and periodontal diseases. This study aims to investigate the levels of OB and s-OB-R in serum and their presence in gingiva of healthy controls (HC), gingivitis (G), aggressive periodontitis (AP), and chronic periodontitis (CP) patients; and whether correlations exist between clinical and serum parameters, OB and s-OB-R. Seventy-seven subjects [HC (n = 20), G (n = 20), CP (n = 21), and AP (n = 16)] were included in this study. After the clinical periodontal parameter recordings and venous blood sampling, gingival tissues obtained. Serum parameters' levels determined with enzyme linked immune sorbent assay; and OB and OB-R in gingiva immunohistochemically. No significant differences were observed regarding the serum parameters [high sensitivity C-reactive protein (hs-CRP), lipids, OB, and s-OB-R] when the groups were compared (P &amp;gt; 0.0125). The serum OB has positive correlations with hs-CRP in the G group (P &amp;lt; 0.05), and s-OB-R has presented significant negative correlations with BOP in HC group (P &amp;lt; 0.05), with hs-CRP in G (P &amp;lt; 0.05) and AP groups (P &amp;lt; 0.05). The positive correlations were observed between the serum OB and HDL and body mass index in the CP group (P &amp;lt; 0.05). In all of the tissue samples of all groups, there was positive OB and OB-R immunoreactivity in the gingival epithelium. The gingival tissues contain both OB and OB-R. The serum levels of OB and s-OB-R do not vary between patients and with different periodontal conditions.</description>
  </descriptions>
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