1 Ocak 2012 Dergi makalesi Açık Erişim

Ay, Zuhal Yetkin; Kirzioglu, F. Yesim; Tonguc, Mine Ozturk; Sutcu, Recep; Kapucuoglu, Nilgun

Citation Style Language JSON

{
  "DOI": "10.1007/s10266-011-0043-0", 
  "abstract": "The presence of leptin (OB) and soluble OB receptor (s-OB-R) in gingival tissue extract and gingival crevicular fluid has led the studies investigating the relationship between OB and periodontal diseases. This study aims to investigate the levels of OB and s-OB-R in serum and their presence in gingiva of healthy controls (HC), gingivitis (G), aggressive periodontitis (AP), and chronic periodontitis (CP) patients; and whether correlations exist between clinical and serum parameters, OB and s-OB-R. Seventy-seven subjects [HC (n = 20), G (n = 20), CP (n = 21), and AP (n = 16)] were included in this study. After the clinical periodontal parameter recordings and venous blood sampling, gingival tissues obtained. Serum parameters' levels determined with enzyme linked immune sorbent assay; and OB and OB-R in gingiva immunohistochemically. No significant differences were observed regarding the serum parameters [high sensitivity C-reactive protein (hs-CRP), lipids, OB, and s-OB-R] when the groups were compared (P > 0.0125). The serum OB has positive correlations with hs-CRP in the G group (P < 0.05), and s-OB-R has presented significant negative correlations with BOP in HC group (P < 0.05), with hs-CRP in G (P < 0.05) and AP groups (P < 0.05). The positive correlations were observed between the serum OB and HDL and body mass index in the CP group (P < 0.05). In all of the tissue samples of all groups, there was positive OB and OB-R immunoreactivity in the gingival epithelium. The gingival tissues contain both OB and OB-R. The serum levels of OB and s-OB-R do not vary between patients and with different periodontal conditions.", 
  "author": [
    {
      "family": "Ay", 
      "given": " Zuhal Yetkin"
    }, 
    {
      "family": "Kirzioglu", 
      "given": " F. Yesim"
    }, 
    {
      "family": "Tonguc", 
      "given": " Mine Ozturk"
    }, 
    {
      "family": "Sutcu", 
      "given": " Recep"
    }, 
    {
      "family": "Kapucuoglu", 
      "given": " Nilgun"
    }
  ], 
  "container_title": "ODONTOLOGY", 
  "id": "83713", 
  "issue": "2", 
  "issued": {
    "date-parts": [
      [
        2012, 
        1, 
        1
      ]
    ]
  }, 
  "page": "222-231", 
  "title": "The gingiva contains leptin and leptin receptor in health and disease", 
  "type": "article-journal", 
  "volume": "100"
}