1 Ocak 2012 Dergi makalesi Açık Erişim

Ay, Zuhal Yetkin; Kirzioglu, F. Yesim; Tonguc, Mine Ozturk; Sutcu, Recep; Kapucuoglu, Nilgun

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    "creators": [
      {
        "affiliation": "Suleyman Demirel Univ, Dept Periodontol, Fac Dent, TR-32260 Isparta, Turkey", 
        "name": "Ay, Zuhal Yetkin"
      }, 
      {
        "affiliation": "Suleyman Demirel Univ, Dept Periodontol, Fac Dent, TR-32260 Isparta, Turkey", 
        "name": "Kirzioglu, F. Yesim"
      }, 
      {
        "affiliation": "Suleyman Demirel Univ, Dept Periodontol, Fac Dent, TR-32260 Isparta, Turkey", 
        "name": "Tonguc, Mine Ozturk"
      }, 
      {
        "affiliation": "Suleyman Demirel Univ, Dept Biochem, Fac Dent, TR-32260 Isparta, Turkey", 
        "name": "Sutcu, Recep"
      }, 
      {
        "affiliation": "Suleyman Demirel Univ, Dept Pathol, Fac Dent, TR-32260 Isparta, Turkey", 
        "name": "Kapucuoglu, Nilgun"
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    ], 
    "description": "The presence of leptin (OB) and soluble OB receptor (s-OB-R) in gingival tissue extract and gingival crevicular fluid has led the studies investigating the relationship between OB and periodontal diseases. This study aims to investigate the levels of OB and s-OB-R in serum and their presence in gingiva of healthy controls (HC), gingivitis (G), aggressive periodontitis (AP), and chronic periodontitis (CP) patients; and whether correlations exist between clinical and serum parameters, OB and s-OB-R. Seventy-seven subjects [HC (n = 20), G (n = 20), CP (n = 21), and AP (n = 16)] were included in this study. After the clinical periodontal parameter recordings and venous blood sampling, gingival tissues obtained. Serum parameters' levels determined with enzyme linked immune sorbent assay; and OB and OB-R in gingiva immunohistochemically. No significant differences were observed regarding the serum parameters [high sensitivity C-reactive protein (hs-CRP), lipids, OB, and s-OB-R] when the groups were compared (P > 0.0125). The serum OB has positive correlations with hs-CRP in the G group (P < 0.05), and s-OB-R has presented significant negative correlations with BOP in HC group (P < 0.05), with hs-CRP in G (P < 0.05) and AP groups (P < 0.05). The positive correlations were observed between the serum OB and HDL and body mass index in the CP group (P < 0.05). In all of the tissue samples of all groups, there was positive OB and OB-R immunoreactivity in the gingival epithelium. The gingival tissues contain both OB and OB-R. The serum levels of OB and s-OB-R do not vary between patients and with different periodontal conditions.", 
    "doi": "10.1007/s10266-011-0043-0", 
    "has_grant": false, 
    "journal": {
      "issue": "2", 
      "pages": "222-231", 
      "title": "ODONTOLOGY", 
      "volume": "100"
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    "license": {
      "id": "cc-by"
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    "publication_date": "2012-01-01", 
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    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
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    "title": "The gingiva contains leptin and leptin receptor in health and disease"
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