1 Ocak 2012 Dergi makalesi Açık Erişim

Ay, Zuhal Yetkin; Kirzioglu, F. Yesim; Tonguc, Mine Ozturk; Sutcu, Recep; Kapucuoglu, Nilgun

Dublin Core

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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Ay, Zuhal Yetkin</dc:creator>
  <dc:creator>Kirzioglu, F. Yesim</dc:creator>
  <dc:creator>Tonguc, Mine Ozturk</dc:creator>
  <dc:creator>Sutcu, Recep</dc:creator>
  <dc:creator>Kapucuoglu, Nilgun</dc:creator>
  <dc:date>2012-01-01</dc:date>
  <dc:description>The presence of leptin (OB) and soluble OB receptor (s-OB-R) in gingival tissue extract and gingival crevicular fluid has led the studies investigating the relationship between OB and periodontal diseases. This study aims to investigate the levels of OB and s-OB-R in serum and their presence in gingiva of healthy controls (HC), gingivitis (G), aggressive periodontitis (AP), and chronic periodontitis (CP) patients; and whether correlations exist between clinical and serum parameters, OB and s-OB-R. Seventy-seven subjects [HC (n = 20), G (n = 20), CP (n = 21), and AP (n = 16)] were included in this study. After the clinical periodontal parameter recordings and venous blood sampling, gingival tissues obtained. Serum parameters' levels determined with enzyme linked immune sorbent assay; and OB and OB-R in gingiva immunohistochemically. No significant differences were observed regarding the serum parameters [high sensitivity C-reactive protein (hs-CRP), lipids, OB, and s-OB-R] when the groups were compared (P &gt; 0.0125). The serum OB has positive correlations with hs-CRP in the G group (P &lt; 0.05), and s-OB-R has presented significant negative correlations with BOP in HC group (P &lt; 0.05), with hs-CRP in G (P &lt; 0.05) and AP groups (P &lt; 0.05). The positive correlations were observed between the serum OB and HDL and body mass index in the CP group (P &lt; 0.05). In all of the tissue samples of all groups, there was positive OB and OB-R immunoreactivity in the gingival epithelium. The gingival tissues contain both OB and OB-R. The serum levels of OB and s-OB-R do not vary between patients and with different periodontal conditions.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/83713</dc:identifier>
  <dc:identifier>oai:zenodo.org:83713</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>ODONTOLOGY 100(2) 222-231</dc:source>
  <dc:title>The gingiva contains leptin and leptin receptor in health and disease</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>