1 Ocak 2012 Dergi makalesi Açık Erişim

Ay, Zuhal Yetkin; Kirzioglu, F. Yesim; Tonguc, Mine Ozturk; Sutcu, Recep; Kapucuoglu, Nilgun

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{
  "@context": "https://schema.org/", 
  "@id": 83713, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Suleyman Demirel Univ, Dept Periodontol, Fac Dent, TR-32260 Isparta, Turkey", 
      "name": "Ay, Zuhal Yetkin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Suleyman Demirel Univ, Dept Periodontol, Fac Dent, TR-32260 Isparta, Turkey", 
      "name": "Kirzioglu, F. Yesim"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Suleyman Demirel Univ, Dept Periodontol, Fac Dent, TR-32260 Isparta, Turkey", 
      "name": "Tonguc, Mine Ozturk"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Suleyman Demirel Univ, Dept Biochem, Fac Dent, TR-32260 Isparta, Turkey", 
      "name": "Sutcu, Recep"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Suleyman Demirel Univ, Dept Pathol, Fac Dent, TR-32260 Isparta, Turkey", 
      "name": "Kapucuoglu, Nilgun"
    }
  ], 
  "datePublished": "2012-01-01", 
  "description": "The presence of leptin (OB) and soluble OB receptor (s-OB-R) in gingival tissue extract and gingival crevicular fluid has led the studies investigating the relationship between OB and periodontal diseases. This study aims to investigate the levels of OB and s-OB-R in serum and their presence in gingiva of healthy controls (HC), gingivitis (G), aggressive periodontitis (AP), and chronic periodontitis (CP) patients; and whether correlations exist between clinical and serum parameters, OB and s-OB-R. Seventy-seven subjects [HC (n = 20), G (n = 20), CP (n = 21), and AP (n = 16)] were included in this study. After the clinical periodontal parameter recordings and venous blood sampling, gingival tissues obtained. Serum parameters' levels determined with enzyme linked immune sorbent assay; and OB and OB-R in gingiva immunohistochemically. No significant differences were observed regarding the serum parameters [high sensitivity C-reactive protein (hs-CRP), lipids, OB, and s-OB-R] when the groups were compared (P > 0.0125). The serum OB has positive correlations with hs-CRP in the G group (P < 0.05), and s-OB-R has presented significant negative correlations with BOP in HC group (P < 0.05), with hs-CRP in G (P < 0.05) and AP groups (P < 0.05). The positive correlations were observed between the serum OB and HDL and body mass index in the CP group (P < 0.05). In all of the tissue samples of all groups, there was positive OB and OB-R immunoreactivity in the gingival epithelium. The gingival tissues contain both OB and OB-R. The serum levels of OB and s-OB-R do not vary between patients and with different periodontal conditions.", 
  "headline": "The gingiva contains leptin and leptin receptor in health and disease", 
  "identifier": 83713, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "The gingiva contains leptin and leptin receptor in health and disease", 
  "url": "https://aperta.ulakbim.gov.tr/record/83713"
}