1 Ocak 2015 Dergi makalesi Açık Erişim

Kordikanlioglu, Burcu; Simsek, Omer; Saris, Per E. J.

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  <dc:creator>Kordikanlioglu, Burcu</dc:creator>
  <dc:creator>Simsek, Omer</dc:creator>
  <dc:creator>Saris, Per E. J.</dc:creator>
  <dc:date>2015-01-01</dc:date>
  <dc:description>In this study, nisin production of Lactococcus lactis N8 was optimized by independent variables of glucose, hemin and oxygen concentrations in fed-batch fermentation in which respiration of cells was stimulated with hemin. Response surface model was able to explain the changes of the nisin production of L. lactis N8 in fed-batch fermentation system with high fidelity (R-2 98%) and insignificant lack of fit. Accordingly, the equation developed indicated the optimum parameters for glucose, hemin, and dissolved oxygen were 8 g L-1 h(-1), 3 mu g mL(-1) and 40%, respectively. While 1711 IU mL(-1) nisin was produced by L. lactis N8 in control fed-batch fermentation, 5410 IU mL(-1) nisin production was achieved within the relevant optimum parameters where the respiration of cell was stimulated with hemin. Accordingly, nisin production was enhanced 3.1 fold in fed-batch fermentation using hemin. In conclusion the nisin production of L. lactis N8 was enhanced extensively as a result of increasing the biomass by stimulating the cell respiration with adding the hemin in the fed-batch fermentation. (C) 2015 American Institute of Chemical Engineers</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/83197</dc:identifier>
  <dc:identifier>oai:zenodo.org:83197</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>BIOTECHNOLOGY PROGRESS 31(3) 678-685</dc:source>
  <dc:title>Nisin Production of Lactococcus lactis N8 with Hemin-Stimulated Cell Respiration in Fed-Batch Fermentation System</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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