1 Ocak 2015 Dergi makalesi Açık Erişim

Kordikanlioglu, Burcu; Simsek, Omer; Saris, Per E. J.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/83197</identifier>
  <creators>
    <creator>
      <creatorName>Kordikanlioglu, Burcu</creatorName>
      <givenName>Burcu</givenName>
      <familyName>Kordikanlioglu</familyName>
      <affiliation>Univ Pamukkale, Dept Food Engn, Denizli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Simsek, Omer</creatorName>
      <givenName>Omer</givenName>
      <familyName>Simsek</familyName>
      <affiliation>Univ Pamukkale, Dept Food Engn, Denizli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Saris, Per E. J.</creatorName>
      <givenName>Per E. J.</givenName>
      <familyName>Saris</familyName>
      <affiliation>Univ Helsinki, Dept Food &amp; Environm Sci, Helsinki, Finland</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Nisin Production Of Lactococcus Lactis N8 With Hemin-Stimulated Cell Respiration In Fed-Batch Fermentation System</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2015</publicationYear>
  <dates>
    <date dateType="Issued">2015-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/83197</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1002/btpr.2075</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">In this study, nisin production of Lactococcus lactis N8 was optimized by independent variables of glucose, hemin and oxygen concentrations in fed-batch fermentation in which respiration of cells was stimulated with hemin. Response surface model was able to explain the changes of the nisin production of L. lactis N8 in fed-batch fermentation system with high fidelity (R-2 98%) and insignificant lack of fit. Accordingly, the equation developed indicated the optimum parameters for glucose, hemin, and dissolved oxygen were 8 g L-1 h(-1), 3 mu g mL(-1) and 40%, respectively. While 1711 IU mL(-1) nisin was produced by L. lactis N8 in control fed-batch fermentation, 5410 IU mL(-1) nisin production was achieved within the relevant optimum parameters where the respiration of cell was stimulated with hemin. Accordingly, nisin production was enhanced 3.1 fold in fed-batch fermentation using hemin. In conclusion the nisin production of L. lactis N8 was enhanced extensively as a result of increasing the biomass by stimulating the cell respiration with adding the hemin in the fed-batch fermentation. (C) 2015 American Institute of Chemical Engineers</description>
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