1 Ocak 2019 Dergi makalesi Açık Erişim

Eken, Ahmet; Cansever, Murat; Somekh, Ido; Mizoguchi, Yoko; Zietara, Natalia; Okus, Fatma Zehra; Erdem, Serife; Canatan, Halit; Akyol, Sefika; Ozcan, Alper; Karakukcu, Musa; Hollizeck, Sebastian; Rohlfs, Meino; Unal, Ekrem; Klein, Christoph; Patiroglu, Turkan

Dublin Core

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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Eken, Ahmet</dc:creator>
  <dc:creator>Cansever, Murat</dc:creator>
  <dc:creator>Somekh, Ido</dc:creator>
  <dc:creator>Mizoguchi, Yoko</dc:creator>
  <dc:creator>Zietara, Natalia</dc:creator>
  <dc:creator>Okus, Fatma Zehra</dc:creator>
  <dc:creator>Erdem, Serife</dc:creator>
  <dc:creator>Canatan, Halit</dc:creator>
  <dc:creator>Akyol, Sefika</dc:creator>
  <dc:creator>Ozcan, Alper</dc:creator>
  <dc:creator>Karakukcu, Musa</dc:creator>
  <dc:creator>Hollizeck, Sebastian</dc:creator>
  <dc:creator>Rohlfs, Meino</dc:creator>
  <dc:creator>Unal, Ekrem</dc:creator>
  <dc:creator>Klein, Christoph</dc:creator>
  <dc:creator>Patiroglu, Turkan</dc:creator>
  <dc:date>2019-01-01</dc:date>
  <dc:description>Purpose Interleukin-2-inducible T cell kinase (ITK) is an important mediator of T cell receptor signaling. Loss of function mutations in ITK results in hypogammaglobulinemia and CD4+ T cell loss in humans, and the patients often present with EBV-associated B cell lymphoproliferative syndrome. Itk-deficient mice show loss of T cell naivety, impaired cytolytic activity of CD8+ T cells, and defects in CD4+ T cell lineage choice decisions. In mice, Itk mutations were shown to affect Th17-Treg lineage choice in favor of the latter. In this study, we explored whether human ITK reciprocally regulates Th17-Treg balance as its murine ortholog.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/74957</dc:identifier>
  <dc:identifier>oai:zenodo.org:74957</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>JOURNAL OF CLINICAL IMMUNOLOGY 39(4) 391-400</dc:source>
  <dc:title>Genetic Deficiency and Biochemical Inhibition of ITK Affect Human Th17, Treg, and Innate Lymphoid Cells</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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