1 Ocak 2019 Dergi makalesi Açık Erişim

Eken, Ahmet; Cansever, Murat; Somekh, Ido; Mizoguchi, Yoko; Zietara, Natalia; Okus, Fatma Zehra; Erdem, Serife; Canatan, Halit; Akyol, Sefika; Ozcan, Alper; Karakukcu, Musa; Hollizeck, Sebastian; Rohlfs, Meino; Unal, Ekrem; Klein, Christoph; Patiroglu, Turkan

Citation Style Language JSON

{
  "DOI": "10.1007/s10875-019-00632-5", 
  "abstract": "Purpose Interleukin-2-inducible T cell kinase (ITK) is an important mediator of T cell receptor signaling. Loss of function mutations in ITK results in hypogammaglobulinemia and CD4+ T cell loss in humans, and the patients often present with EBV-associated B cell lymphoproliferative syndrome. Itk-deficient mice show loss of T cell naivety, impaired cytolytic activity of CD8+ T cells, and defects in CD4+ T cell lineage choice decisions. In mice, Itk mutations were shown to affect Th17-Treg lineage choice in favor of the latter. In this study, we explored whether human ITK reciprocally regulates Th17-Treg balance as its murine ortholog.", 
  "author": [
    {
      "family": "Eken", 
      "given": " Ahmet"
    }, 
    {
      "family": "Cansever", 
      "given": " Murat"
    }, 
    {
      "family": "Somekh", 
      "given": " Ido"
    }, 
    {
      "family": "Mizoguchi", 
      "given": " Yoko"
    }, 
    {
      "family": "Zietara", 
      "given": " Natalia"
    }, 
    {
      "family": "Okus", 
      "given": " Fatma Zehra"
    }, 
    {
      "family": "Erdem", 
      "given": " Serife"
    }, 
    {
      "family": "Canatan", 
      "given": " Halit"
    }, 
    {
      "family": "Akyol", 
      "given": " Sefika"
    }, 
    {
      "family": "Ozcan", 
      "given": " Alper"
    }, 
    {
      "family": "Karakukcu", 
      "given": " Musa"
    }, 
    {
      "family": "Hollizeck", 
      "given": " Sebastian"
    }, 
    {
      "family": "Rohlfs", 
      "given": " Meino"
    }, 
    {
      "family": "Unal", 
      "given": " Ekrem"
    }, 
    {
      "family": "Klein", 
      "given": " Christoph"
    }, 
    {
      "family": "Patiroglu", 
      "given": " Turkan"
    }
  ], 
  "container_title": "JOURNAL OF CLINICAL IMMUNOLOGY", 
  "id": "74957", 
  "issue": "4", 
  "issued": {
    "date-parts": [
      [
        2019, 
        1, 
        1
      ]
    ]
  }, 
  "page": "391-400", 
  "title": "Genetic Deficiency and Biochemical Inhibition of ITK Affect Human Th17, Treg, and Innate Lymphoid Cells", 
  "type": "article-journal", 
  "volume": "39"
}