1 Ocak 2019 Dergi makalesi Açık Erişim

Eken, Ahmet; Cansever, Murat; Somekh, Ido; Mizoguchi, Yoko; Zietara, Natalia; Okus, Fatma Zehra; Erdem, Serife; Canatan, Halit; Akyol, Sefika; Ozcan, Alper; Karakukcu, Musa; Hollizeck, Sebastian; Rohlfs, Meino; Unal, Ekrem; Klein, Christoph; Patiroglu, Turkan

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/74957</identifier>
  <creators>
    <creator>
      <creatorName>Eken, Ahmet</creatorName>
      <givenName>Ahmet</givenName>
      <familyName>Eken</familyName>
      <affiliation>Erciyes Univ, Genome &amp; Stem Cell Ctr GENKOK, Dept Med Biol, Fac Med, TR-38030 Kayseri, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Cansever, Murat</creatorName>
      <givenName>Murat</givenName>
      <familyName>Cansever</familyName>
      <affiliation>Erciyes Univ, Div Pediat Hematol Oncol, Dept Pediat, Fac Med, TR-38030 Kayseri, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Somekh, Ido</creatorName>
      <givenName>Ido</givenName>
      <familyName>Somekh</familyName>
      <affiliation>Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Pediat, Dr von Hauner Childrens Hosp, Munich, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Mizoguchi, Yoko</creatorName>
      <givenName>Yoko</givenName>
      <familyName>Mizoguchi</familyName>
      <affiliation>Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Pediat, Dr von Hauner Childrens Hosp, Munich, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Zietara, Natalia</creatorName>
      <givenName>Natalia</givenName>
      <familyName>Zietara</familyName>
      <affiliation>Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Pediat, Dr von Hauner Childrens Hosp, Munich, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Okus, Fatma Zehra</creatorName>
      <givenName>Fatma Zehra</givenName>
      <familyName>Okus</familyName>
      <affiliation>Erciyes Univ, Genome &amp; Stem Cell Ctr GENKOK, Dept Med Biol, Fac Med, TR-38030 Kayseri, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Erdem, Serife</creatorName>
      <givenName>Serife</givenName>
      <familyName>Erdem</familyName>
      <affiliation>Erciyes Univ, Genome &amp; Stem Cell Ctr GENKOK, Dept Med Biol, Fac Med, TR-38030 Kayseri, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Canatan, Halit</creatorName>
      <givenName>Halit</givenName>
      <familyName>Canatan</familyName>
      <affiliation>Erciyes Univ, Genome &amp; Stem Cell Ctr GENKOK, Dept Med Biol, Fac Med, TR-38030 Kayseri, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akyol, Sefika</creatorName>
      <givenName>Sefika</givenName>
      <familyName>Akyol</familyName>
      <affiliation>Erciyes Univ, Div Pediat Hematol Oncol, Dept Pediat, Fac Med, TR-38030 Kayseri, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozcan, Alper</creatorName>
      <givenName>Alper</givenName>
      <familyName>Ozcan</familyName>
      <affiliation>Erciyes Univ, Div Pediat Hematol Oncol, Dept Pediat, Fac Med, TR-38030 Kayseri, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Karakukcu, Musa</creatorName>
      <givenName>Musa</givenName>
      <familyName>Karakukcu</familyName>
      <affiliation>Erciyes Univ, Div Pediat Hematol Oncol, Dept Pediat, Fac Med, TR-38030 Kayseri, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Hollizeck, Sebastian</creatorName>
      <givenName>Sebastian</givenName>
      <familyName>Hollizeck</familyName>
      <affiliation>Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Pediat, Dr von Hauner Childrens Hosp, Munich, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Rohlfs, Meino</creatorName>
      <givenName>Meino</givenName>
      <familyName>Rohlfs</familyName>
      <affiliation>Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Pediat, Dr von Hauner Childrens Hosp, Munich, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Unal, Ekrem</creatorName>
      <givenName>Ekrem</givenName>
      <familyName>Unal</familyName>
      <affiliation>Erciyes Univ, Div Pediat Hematol Oncol, Dept Pediat, Fac Med, TR-38030 Kayseri, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Klein, Christoph</creatorName>
      <givenName>Christoph</givenName>
      <familyName>Klein</familyName>
      <affiliation>Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Pediat, Dr von Hauner Childrens Hosp, Munich, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Patiroglu, Turkan</creatorName>
      <givenName>Turkan</givenName>
      <familyName>Patiroglu</familyName>
      <affiliation>Erciyes Univ, Div Pediat Hematol Oncol, Dept Pediat, Fac Med, TR-38030 Kayseri, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Genetic Deficiency And Biochemical Inhibition Of Itk Affect Human Th17, Treg, And Innate Lymphoid Cells</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/74957</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s10875-019-00632-5</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Purpose Interleukin-2-inducible T cell kinase (ITK) is an important mediator of T cell receptor signaling. Loss of function mutations in ITK results in hypogammaglobulinemia and CD4+ T cell loss in humans, and the patients often present with EBV-associated B cell lymphoproliferative syndrome. Itk-deficient mice show loss of T cell naivety, impaired cytolytic activity of CD8+ T cells, and defects in CD4+ T cell lineage choice decisions. In mice, Itk mutations were shown to affect Th17-Treg lineage choice in favor of the latter. In this study, we explored whether human ITK reciprocally regulates Th17-Treg balance as its murine ortholog.</description>
  </descriptions>
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