1 Ocak 2019 Dergi makalesi Açık Erişim

Eken, Ahmet; Cansever, Murat; Somekh, Ido; Mizoguchi, Yoko; Zietara, Natalia; Okus, Fatma Zehra; Erdem, Serife; Canatan, Halit; Akyol, Sefika; Ozcan, Alper; Karakukcu, Musa; Hollizeck, Sebastian; Rohlfs, Meino; Unal, Ekrem; Klein, Christoph; Patiroglu, Turkan

JSON-LD (schema.org)

{
  "@context": "https://schema.org/", 
  "@id": 74957, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Erciyes Univ, Genome & Stem Cell Ctr GENKOK, Dept Med Biol, Fac Med, TR-38030 Kayseri, Turkey", 
      "name": "Eken, Ahmet"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Erciyes Univ, Div Pediat Hematol Oncol, Dept Pediat, Fac Med, TR-38030 Kayseri, Turkey", 
      "name": "Cansever, Murat"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Pediat, Dr von Hauner Childrens Hosp, Munich, Germany", 
      "name": "Somekh, Ido"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Pediat, Dr von Hauner Childrens Hosp, Munich, Germany", 
      "name": "Mizoguchi, Yoko"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Pediat, Dr von Hauner Childrens Hosp, Munich, Germany", 
      "name": "Zietara, Natalia"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Erciyes Univ, Genome & Stem Cell Ctr GENKOK, Dept Med Biol, Fac Med, TR-38030 Kayseri, Turkey", 
      "name": "Okus, Fatma Zehra"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Erciyes Univ, Genome & Stem Cell Ctr GENKOK, Dept Med Biol, Fac Med, TR-38030 Kayseri, Turkey", 
      "name": "Erdem, Serife"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Erciyes Univ, Genome & Stem Cell Ctr GENKOK, Dept Med Biol, Fac Med, TR-38030 Kayseri, Turkey", 
      "name": "Canatan, Halit"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Erciyes Univ, Div Pediat Hematol Oncol, Dept Pediat, Fac Med, TR-38030 Kayseri, Turkey", 
      "name": "Akyol, Sefika"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Erciyes Univ, Div Pediat Hematol Oncol, Dept Pediat, Fac Med, TR-38030 Kayseri, Turkey", 
      "name": "Ozcan, Alper"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Erciyes Univ, Div Pediat Hematol Oncol, Dept Pediat, Fac Med, TR-38030 Kayseri, Turkey", 
      "name": "Karakukcu, Musa"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Pediat, Dr von Hauner Childrens Hosp, Munich, Germany", 
      "name": "Hollizeck, Sebastian"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Pediat, Dr von Hauner Childrens Hosp, Munich, Germany", 
      "name": "Rohlfs, Meino"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Erciyes Univ, Div Pediat Hematol Oncol, Dept Pediat, Fac Med, TR-38030 Kayseri, Turkey", 
      "name": "Unal, Ekrem"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Pediat, Dr von Hauner Childrens Hosp, Munich, Germany", 
      "name": "Klein, Christoph"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Erciyes Univ, Div Pediat Hematol Oncol, Dept Pediat, Fac Med, TR-38030 Kayseri, Turkey", 
      "name": "Patiroglu, Turkan"
    }
  ], 
  "datePublished": "2019-01-01", 
  "description": "Purpose Interleukin-2-inducible T cell kinase (ITK) is an important mediator of T cell receptor signaling. Loss of function mutations in ITK results in hypogammaglobulinemia and CD4+ T cell loss in humans, and the patients often present with EBV-associated B cell lymphoproliferative syndrome. Itk-deficient mice show loss of T cell naivety, impaired cytolytic activity of CD8+ T cells, and defects in CD4+ T cell lineage choice decisions. In mice, Itk mutations were shown to affect Th17-Treg lineage choice in favor of the latter. In this study, we explored whether human ITK reciprocally regulates Th17-Treg balance as its murine ortholog.", 
  "headline": "Genetic Deficiency and Biochemical Inhibition of ITK Affect Human Th17, Treg, and Innate Lymphoid Cells", 
  "identifier": 74957, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Genetic Deficiency and Biochemical Inhibition of ITK Affect Human Th17, Treg, and Innate Lymphoid Cells", 
  "url": "https://aperta.ulakbim.gov.tr/record/74957"
}