1 Ocak 2019 Dergi makalesi Açık Erişim

Eken, Ahmet; Cansever, Murat; Somekh, Ido; Mizoguchi, Yoko; Zietara, Natalia; Okus, Fatma Zehra; Erdem, Serife; Canatan, Halit; Akyol, Sefika; Ozcan, Alper; Karakukcu, Musa; Hollizeck, Sebastian; Rohlfs, Meino; Unal, Ekrem; Klein, Christoph; Patiroglu, Turkan

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    "creators": [
      {
        "affiliation": "Erciyes Univ, Genome & Stem Cell Ctr GENKOK, Dept Med Biol, Fac Med, TR-38030 Kayseri, Turkey", 
        "name": "Eken, Ahmet"
      }, 
      {
        "affiliation": "Erciyes Univ, Div Pediat Hematol Oncol, Dept Pediat, Fac Med, TR-38030 Kayseri, Turkey", 
        "name": "Cansever, Murat"
      }, 
      {
        "affiliation": "Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Pediat, Dr von Hauner Childrens Hosp, Munich, Germany", 
        "name": "Somekh, Ido"
      }, 
      {
        "affiliation": "Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Pediat, Dr von Hauner Childrens Hosp, Munich, Germany", 
        "name": "Mizoguchi, Yoko"
      }, 
      {
        "affiliation": "Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Pediat, Dr von Hauner Childrens Hosp, Munich, Germany", 
        "name": "Zietara, Natalia"
      }, 
      {
        "affiliation": "Erciyes Univ, Genome & Stem Cell Ctr GENKOK, Dept Med Biol, Fac Med, TR-38030 Kayseri, Turkey", 
        "name": "Okus, Fatma Zehra"
      }, 
      {
        "affiliation": "Erciyes Univ, Genome & Stem Cell Ctr GENKOK, Dept Med Biol, Fac Med, TR-38030 Kayseri, Turkey", 
        "name": "Erdem, Serife"
      }, 
      {
        "affiliation": "Erciyes Univ, Genome & Stem Cell Ctr GENKOK, Dept Med Biol, Fac Med, TR-38030 Kayseri, Turkey", 
        "name": "Canatan, Halit"
      }, 
      {
        "affiliation": "Erciyes Univ, Div Pediat Hematol Oncol, Dept Pediat, Fac Med, TR-38030 Kayseri, Turkey", 
        "name": "Akyol, Sefika"
      }, 
      {
        "affiliation": "Erciyes Univ, Div Pediat Hematol Oncol, Dept Pediat, Fac Med, TR-38030 Kayseri, Turkey", 
        "name": "Ozcan, Alper"
      }, 
      {
        "affiliation": "Erciyes Univ, Div Pediat Hematol Oncol, Dept Pediat, Fac Med, TR-38030 Kayseri, Turkey", 
        "name": "Karakukcu, Musa"
      }, 
      {
        "affiliation": "Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Pediat, Dr von Hauner Childrens Hosp, Munich, Germany", 
        "name": "Hollizeck, Sebastian"
      }, 
      {
        "affiliation": "Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Pediat, Dr von Hauner Childrens Hosp, Munich, Germany", 
        "name": "Rohlfs, Meino"
      }, 
      {
        "affiliation": "Erciyes Univ, Div Pediat Hematol Oncol, Dept Pediat, Fac Med, TR-38030 Kayseri, Turkey", 
        "name": "Unal, Ekrem"
      }, 
      {
        "affiliation": "Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Pediat, Dr von Hauner Childrens Hosp, Munich, Germany", 
        "name": "Klein, Christoph"
      }, 
      {
        "affiliation": "Erciyes Univ, Div Pediat Hematol Oncol, Dept Pediat, Fac Med, TR-38030 Kayseri, Turkey", 
        "name": "Patiroglu, Turkan"
      }
    ], 
    "description": "Purpose Interleukin-2-inducible T cell kinase (ITK) is an important mediator of T cell receptor signaling. Loss of function mutations in ITK results in hypogammaglobulinemia and CD4+ T cell loss in humans, and the patients often present with EBV-associated B cell lymphoproliferative syndrome. Itk-deficient mice show loss of T cell naivety, impaired cytolytic activity of CD8+ T cells, and defects in CD4+ T cell lineage choice decisions. In mice, Itk mutations were shown to affect Th17-Treg lineage choice in favor of the latter. In this study, we explored whether human ITK reciprocally regulates Th17-Treg balance as its murine ortholog.", 
    "doi": "10.1007/s10875-019-00632-5", 
    "has_grant": false, 
    "journal": {
      "issue": "4", 
      "pages": "391-400", 
      "title": "JOURNAL OF CLINICAL IMMUNOLOGY", 
      "volume": "39"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2019-01-01", 
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    "resource_type": {
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      "title": "Dergi makalesi", 
      "type": "publication"
    }, 
    "title": "Genetic Deficiency and Biochemical Inhibition of ITK Affect Human Th17, Treg, and Innate Lymphoid Cells"
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