1 Ocak 2014 Dergi makalesi Açık Erişim

Altug, Cevher; Buyukbayram, Muhammet; Kavas, Ozge; Yavuz, Muhsine Zeynep

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    <subfield code="a">The present work describes a new protocol for the synthesis of 5-aminoisoxazoles using alpha-chlorooximes and 2-phenylsulfonyl acetonitrile via green chemistry routes. The titled 5-aminoisoxazoles 3 were further reacted with 4-nitrobenzoyl chloride to obtain 5-amidoisoxazoles with moderate yields. These heterocyclic compounds were tested in vitro MTT study to investigate inhibitive abilities to some cancer cell lines (C3a, L929, T98g and Mcf-7) and compounds 3a, 3c, 3e and 3h showed noticeable cytotoxic property against four cancer cell lines. (C) 2014 Elsevier Ltd. All rights reserved.</subfield>
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    <subfield code="a">A green synthesis of new 3-aryl-4-phenylsulfonyl-5-aminoisoxazoles</subfield>
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