1 Ocak 2014 Dergi makalesi Açık Erişim

Altug, Cevher; Buyukbayram, Muhammet; Kavas, Ozge; Yavuz, Muhsine Zeynep

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/63689</identifier>
  <creators>
    <creator>
      <creatorName>Altug, Cevher</creatorName>
      <givenName>Cevher</givenName>
      <familyName>Altug</familyName>
      <affiliation>Abant Izzet Baysal Univ, Dept Chem, TR-14280 Bolu, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Buyukbayram, Muhammet</creatorName>
      <givenName>Muhammet</givenName>
      <familyName>Buyukbayram</familyName>
      <affiliation>Abant Izzet Baysal Univ, Dept Chem, TR-14280 Bolu, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kavas, Ozge</creatorName>
      <givenName>Ozge</givenName>
      <familyName>Kavas</familyName>
      <affiliation>Abant Izzet Baysal Univ, Dept Chem, TR-14280 Bolu, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yavuz, Muhsine Zeynep</creatorName>
      <givenName>Muhsine Zeynep</givenName>
      <familyName>Yavuz</familyName>
      <affiliation>Abant Izzet Baysal Univ, Fac Med, Dept Med Pharmacol, TR-14280 Bolu, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>A Green Synthesis Of New 3-Aryl-4-Phenylsulfonyl-5-Aminoisoxazoles</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2014</publicationYear>
  <dates>
    <date dateType="Issued">2014-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/63689</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.tet.2014.03.106</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The present work describes a new protocol for the synthesis of 5-aminoisoxazoles using alpha-chlorooximes and 2-phenylsulfonyl acetonitrile via green chemistry routes. The titled 5-aminoisoxazoles 3 were further reacted with 4-nitrobenzoyl chloride to obtain 5-amidoisoxazoles with moderate yields. These heterocyclic compounds were tested in vitro MTT study to investigate inhibitive abilities to some cancer cell lines (C3a, L929, T98g and Mcf-7) and compounds 3a, 3c, 3e and 3h showed noticeable cytotoxic property against four cancer cell lines. (C) 2014 Elsevier Ltd. All rights reserved.</description>
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