1 Ocak 2014 Dergi makalesi Açık Erişim

Altug, Cevher; Buyukbayram, Muhammet; Kavas, Ozge; Yavuz, Muhsine Zeynep

Citation Style Language JSON

{
  "DOI": "10.1016/j.tet.2014.03.106", 
  "abstract": "The present work describes a new protocol for the synthesis of 5-aminoisoxazoles using alpha-chlorooximes and 2-phenylsulfonyl acetonitrile via green chemistry routes. The titled 5-aminoisoxazoles 3 were further reacted with 4-nitrobenzoyl chloride to obtain 5-amidoisoxazoles with moderate yields. These heterocyclic compounds were tested in vitro MTT study to investigate inhibitive abilities to some cancer cell lines (C3a, L929, T98g and Mcf-7) and compounds 3a, 3c, 3e and 3h showed noticeable cytotoxic property against four cancer cell lines. (C) 2014 Elsevier Ltd. All rights reserved.", 
  "author": [
    {
      "family": "Altug", 
      "given": " Cevher"
    }, 
    {
      "family": "Buyukbayram", 
      "given": " Muhammet"
    }, 
    {
      "family": "Kavas", 
      "given": " Ozge"
    }, 
    {
      "family": "Yavuz", 
      "given": " Muhsine Zeynep"
    }
  ], 
  "container_title": "TETRAHEDRON", 
  "id": "63689", 
  "issue": "22", 
  "issued": {
    "date-parts": [
      [
        2014, 
        1, 
        1
      ]
    ]
  }, 
  "page": "3590-3594", 
  "title": "A green synthesis of new 3-aryl-4-phenylsulfonyl-5-aminoisoxazoles", 
  "type": "article-journal", 
  "volume": "70"
}