1 Ocak 2014 Dergi makalesi Açık Erişim

Altug, Cevher; Buyukbayram, Muhammet; Kavas, Ozge; Yavuz, Muhsine Zeynep

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{
  "@context": "https://schema.org/", 
  "@id": 63689, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Abant Izzet Baysal Univ, Dept Chem, TR-14280 Bolu, Turkey", 
      "name": "Altug, Cevher"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Abant Izzet Baysal Univ, Dept Chem, TR-14280 Bolu, Turkey", 
      "name": "Buyukbayram, Muhammet"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Abant Izzet Baysal Univ, Dept Chem, TR-14280 Bolu, Turkey", 
      "name": "Kavas, Ozge"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Abant Izzet Baysal Univ, Fac Med, Dept Med Pharmacol, TR-14280 Bolu, Turkey", 
      "name": "Yavuz, Muhsine Zeynep"
    }
  ], 
  "datePublished": "2014-01-01", 
  "description": "The present work describes a new protocol for the synthesis of 5-aminoisoxazoles using alpha-chlorooximes and 2-phenylsulfonyl acetonitrile via green chemistry routes. The titled 5-aminoisoxazoles 3 were further reacted with 4-nitrobenzoyl chloride to obtain 5-amidoisoxazoles with moderate yields. These heterocyclic compounds were tested in vitro MTT study to investigate inhibitive abilities to some cancer cell lines (C3a, L929, T98g and Mcf-7) and compounds 3a, 3c, 3e and 3h showed noticeable cytotoxic property against four cancer cell lines. (C) 2014 Elsevier Ltd. All rights reserved.", 
  "headline": "A green synthesis of new 3-aryl-4-phenylsulfonyl-5-aminoisoxazoles", 
  "identifier": 63689, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "A green synthesis of new 3-aryl-4-phenylsulfonyl-5-aminoisoxazoles", 
  "url": "https://aperta.ulakbim.gov.tr/record/63689"
}