1 Ocak 2016 Dergi makalesi Açık Erişim

Asav, Engin; Sagiroglu, Ayten; Sezginturk, Mustafa Kemal

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  <dc:creator>Asav, Engin</dc:creator>
  <dc:creator>Sagiroglu, Ayten</dc:creator>
  <dc:creator>Sezginturk, Mustafa Kemal</dc:creator>
  <dc:date>2016-01-01</dc:date>
  <dc:description>Calretinin (CAL) is calcium binding protein, and its levels in blood and cerebrospinal fluids are increased, since its expression is increased various cancer types. A novel biosensor system fabricated by immobilization of a specific antibody to CAL, anti-Calretinin (anti-CAL), onto a gold electrode surface via an effective covalent binding method using mercaptohexanol, epichlorohydrin, and ethanolamine was reported for the sensitive, selective, and accurate analysis of CAL. The proposed biosensor showed a linear calibration range between 1 ng/mL and 5 ng/mL. LOD and LOQ values were determined as 0.11 ng/mL and 0.38 ng/mL, respectively. The standard deviation related to the reproducibility of the new biosensor system was calculated as 3.95%. Lastly, in order to state the applicability of the biosensor to early diagnosis of CAL in practice, artificial serum samples spiked with CAL have been analyzed by the proposed biosensor.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/59215</dc:identifier>
  <dc:identifier>oai:zenodo.org:59215</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>ELECTROANALYSIS 28(2) 334-342</dc:source>
  <dc:title>Quantitative Analysis of a Promising Cancer Biomarker, Calretinin, by a Biosensing System Based on Simple and Effective Immobilization Process</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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