1 Ocak 2016 Dergi makalesi Açık Erişim

Asav, Engin; Sagiroglu, Ayten; Sezginturk, Mustafa Kemal

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        "affiliation": "Kirklareli Univ, Sch Hlth, TR-39000 Kirklareli, Turkey", 
        "name": "Asav, Engin"
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      {
        "affiliation": "Trakya Univ, Fac Sci, Dept Chem, TR-22030 Edirne, Turkey", 
        "name": "Sagiroglu, Ayten"
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      {
        "affiliation": "Namik Kemal Univ, Fac Sci, Dept Chem, Tekirdag, Turkey", 
        "name": "Sezginturk, Mustafa Kemal"
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    "description": "Calretinin (CAL) is calcium binding protein, and its levels in blood and cerebrospinal fluids are increased, since its expression is increased various cancer types. A novel biosensor system fabricated by immobilization of a specific antibody to CAL, anti-Calretinin (anti-CAL), onto a gold electrode surface via an effective covalent binding method using mercaptohexanol, epichlorohydrin, and ethanolamine was reported for the sensitive, selective, and accurate analysis of CAL. The proposed biosensor showed a linear calibration range between 1 ng/mL and 5 ng/mL. LOD and LOQ values were determined as 0.11 ng/mL and 0.38 ng/mL, respectively. The standard deviation related to the reproducibility of the new biosensor system was calculated as 3.95%. Lastly, in order to state the applicability of the biosensor to early diagnosis of CAL in practice, artificial serum samples spiked with CAL have been analyzed by the proposed biosensor.", 
    "doi": "10.1002/elan.201500324", 
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      "issue": "2", 
      "pages": "334-342", 
      "title": "ELECTROANALYSIS", 
      "volume": "28"
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    "title": "Quantitative Analysis of a Promising Cancer Biomarker, Calretinin, by a Biosensing System Based on Simple and Effective Immobilization Process"
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