1 Ocak 2016 Dergi makalesi Açık Erişim

Asav, Engin; Sagiroglu, Ayten; Sezginturk, Mustafa Kemal

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/59215</identifier>
  <creators>
    <creator>
      <creatorName>Asav, Engin</creatorName>
      <givenName>Engin</givenName>
      <familyName>Asav</familyName>
      <affiliation>Kirklareli Univ, Sch Hlth, TR-39000 Kirklareli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sagiroglu, Ayten</creatorName>
      <givenName>Ayten</givenName>
      <familyName>Sagiroglu</familyName>
      <affiliation>Trakya Univ, Fac Sci, Dept Chem, TR-22030 Edirne, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sezginturk, Mustafa Kemal</creatorName>
      <givenName>Mustafa Kemal</givenName>
      <familyName>Sezginturk</familyName>
      <affiliation>Namik Kemal Univ, Fac Sci, Dept Chem, Tekirdag, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Quantitative Analysis Of A Promising Cancer Biomarker, Calretinin, By A Biosensing System Based On Simple And Effective Immobilization Process</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2016</publicationYear>
  <dates>
    <date dateType="Issued">2016-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/59215</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1002/elan.201500324</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Calretinin (CAL) is calcium binding protein, and its levels in blood and cerebrospinal fluids are increased, since its expression is increased various cancer types. A novel biosensor system fabricated by immobilization of a specific antibody to CAL, anti-Calretinin (anti-CAL), onto a gold electrode surface via an effective covalent binding method using mercaptohexanol, epichlorohydrin, and ethanolamine was reported for the sensitive, selective, and accurate analysis of CAL. The proposed biosensor showed a linear calibration range between 1 ng/mL and 5 ng/mL. LOD and LOQ values were determined as 0.11 ng/mL and 0.38 ng/mL, respectively. The standard deviation related to the reproducibility of the new biosensor system was calculated as 3.95%. Lastly, in order to state the applicability of the biosensor to early diagnosis of CAL in practice, artificial serum samples spiked with CAL have been analyzed by the proposed biosensor.</description>
  </descriptions>
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