1 Ocak 2016 Dergi makalesi Açık Erişim

Asav, Engin; Sagiroglu, Ayten; Sezginturk, Mustafa Kemal

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{
  "@context": "https://schema.org/", 
  "@id": 59215, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Kirklareli Univ, Sch Hlth, TR-39000 Kirklareli, Turkey", 
      "name": "Asav, Engin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Trakya Univ, Fac Sci, Dept Chem, TR-22030 Edirne, Turkey", 
      "name": "Sagiroglu, Ayten"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Namik Kemal Univ, Fac Sci, Dept Chem, Tekirdag, Turkey", 
      "name": "Sezginturk, Mustafa Kemal"
    }
  ], 
  "datePublished": "2016-01-01", 
  "description": "Calretinin (CAL) is calcium binding protein, and its levels in blood and cerebrospinal fluids are increased, since its expression is increased various cancer types. A novel biosensor system fabricated by immobilization of a specific antibody to CAL, anti-Calretinin (anti-CAL), onto a gold electrode surface via an effective covalent binding method using mercaptohexanol, epichlorohydrin, and ethanolamine was reported for the sensitive, selective, and accurate analysis of CAL. The proposed biosensor showed a linear calibration range between 1 ng/mL and 5 ng/mL. LOD and LOQ values were determined as 0.11 ng/mL and 0.38 ng/mL, respectively. The standard deviation related to the reproducibility of the new biosensor system was calculated as 3.95%. Lastly, in order to state the applicability of the biosensor to early diagnosis of CAL in practice, artificial serum samples spiked with CAL have been analyzed by the proposed biosensor.", 
  "headline": "Quantitative Analysis of a Promising Cancer Biomarker, Calretinin, by a Biosensing System Based on Simple and Effective Immobilization Process", 
  "identifier": 59215, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Quantitative Analysis of a Promising Cancer Biomarker, Calretinin, by a Biosensing System Based on Simple and Effective Immobilization Process", 
  "url": "https://aperta.ulakbim.gov.tr/record/59215"
}