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Evaluation of Tc-99m-amoxicillin sodium as an infection imaging agent in bacterially infected and sterile inflamed rats

Ilem-Ozdemir, Derya; Caglayan-Orumlu, Oya; Asikoglu, Makbule; Ozkilic, Hayal; Yilmaz, Ferda; Hosgor-Limoncu, Mine


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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Ilem-Ozdemir, Derya</dc:creator>
  <dc:creator>Caglayan-Orumlu, Oya</dc:creator>
  <dc:creator>Asikoglu, Makbule</dc:creator>
  <dc:creator>Ozkilic, Hayal</dc:creator>
  <dc:creator>Yilmaz, Ferda</dc:creator>
  <dc:creator>Hosgor-Limoncu, Mine</dc:creator>
  <dc:date>2016-01-01</dc:date>
  <dc:description>Bacterial infection is one of the major causes of morbidity and mortality especially in developing countries. The aim of this study was to develop a new radiopharmaceutical for imaging infection. The labeling conditions were optimized, and lyophilized kits were developed for instant preparing. The stability of Tc-99m-AMOX in human serum was identified, sterility and pyrogenicity of the radiopharmaceutical were estimated, gamma scintigraphy and in vivo biodistribution with infected rats were investigated. The promising properties of Tc-99m-AMOX combined with the development of reliable and instant lyophilized kit afford the opportunity of inflammatory process imaging.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/55197</dc:identifier>
  <dc:identifier>oai:zenodo.org:55197</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 308(3) 995-1004</dc:source>
  <dc:title>Evaluation of Tc-99m-amoxicillin sodium as an infection imaging agent in bacterially infected and sterile inflamed rats</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>
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