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Evaluation of Tc-99m-amoxicillin sodium as an infection imaging agent in bacterially infected and sterile inflamed rats

Ilem-Ozdemir, Derya; Caglayan-Orumlu, Oya; Asikoglu, Makbule; Ozkilic, Hayal; Yilmaz, Ferda; Hosgor-Limoncu, Mine


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      {
        "affiliation": "Ege Univ, Fac Pharm, Dept Radiopharm, Izmir, Turkey", 
        "name": "Ilem-Ozdemir, Derya"
      }, 
      {
        "affiliation": "Ege Univ, Fac Pharm, Dept Radiopharm, Izmir, Turkey", 
        "name": "Caglayan-Orumlu, Oya"
      }, 
      {
        "affiliation": "Ege Univ, Fac Pharm, Dept Radiopharm, Izmir, Turkey", 
        "name": "Asikoglu, Makbule"
      }, 
      {
        "affiliation": "Ege Univ, Dept Nucl Med, Fac Med, Izmir, Turkey", 
        "name": "Ozkilic, Hayal"
      }, 
      {
        "affiliation": "Ege Univ, Dept Pharmaceut Microbiol, Fac Pharm, Izmir, Turkey", 
        "name": "Yilmaz, Ferda"
      }, 
      {
        "affiliation": "Ege Univ, Dept Pharmaceut Microbiol, Fac Pharm, Izmir, Turkey", 
        "name": "Hosgor-Limoncu, Mine"
      }
    ], 
    "description": "Bacterial infection is one of the major causes of morbidity and mortality especially in developing countries. The aim of this study was to develop a new radiopharmaceutical for imaging infection. The labeling conditions were optimized, and lyophilized kits were developed for instant preparing. The stability of Tc-99m-AMOX in human serum was identified, sterility and pyrogenicity of the radiopharmaceutical were estimated, gamma scintigraphy and in vivo biodistribution with infected rats were investigated. The promising properties of Tc-99m-AMOX combined with the development of reliable and instant lyophilized kit afford the opportunity of inflammatory process imaging.", 
    "doi": "10.1007/s10967-015-4516-4", 
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    "journal": {
      "issue": "3", 
      "pages": "995-1004", 
      "title": "JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY", 
      "volume": "308"
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    "publication_date": "2016-01-01", 
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    "title": "Evaluation of Tc-99m-amoxicillin sodium as an infection imaging agent in bacterially infected and sterile inflamed rats"
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