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Evaluation of Tc-99m-amoxicillin sodium as an infection imaging agent in bacterially infected and sterile inflamed rats

Ilem-Ozdemir, Derya; Caglayan-Orumlu, Oya; Asikoglu, Makbule; Ozkilic, Hayal; Yilmaz, Ferda; Hosgor-Limoncu, Mine


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{
  "DOI": "10.1007/s10967-015-4516-4", 
  "abstract": "Bacterial infection is one of the major causes of morbidity and mortality especially in developing countries. The aim of this study was to develop a new radiopharmaceutical for imaging infection. The labeling conditions were optimized, and lyophilized kits were developed for instant preparing. The stability of Tc-99m-AMOX in human serum was identified, sterility and pyrogenicity of the radiopharmaceutical were estimated, gamma scintigraphy and in vivo biodistribution with infected rats were investigated. The promising properties of Tc-99m-AMOX combined with the development of reliable and instant lyophilized kit afford the opportunity of inflammatory process imaging.", 
  "author": [
    {
      "family": "Ilem-Ozdemir", 
      "given": " Derya"
    }, 
    {
      "family": "Caglayan-Orumlu", 
      "given": " Oya"
    }, 
    {
      "family": "Asikoglu", 
      "given": " Makbule"
    }, 
    {
      "family": "Ozkilic", 
      "given": " Hayal"
    }, 
    {
      "family": "Yilmaz", 
      "given": " Ferda"
    }, 
    {
      "family": "Hosgor-Limoncu", 
      "given": " Mine"
    }
  ], 
  "container_title": "JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY", 
  "id": "55197", 
  "issue": "3", 
  "issued": {
    "date-parts": [
      [
        2016, 
        1, 
        1
      ]
    ]
  }, 
  "page": "995-1004", 
  "title": "Evaluation of Tc-99m-amoxicillin sodium as an infection imaging agent in bacterially infected and sterile inflamed rats", 
  "type": "article-journal", 
  "volume": "308"
}
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