1 Ocak 2016 Dergi makalesi Açık Erişim

Oke-Altuntas, Feyza; Kapche, Gilbert D. W. F.; Ouete, Judith L. Nantchouang; Demirtas, Ibrahim; Koc, Merve B.; Ngadjui, Bonaventure T.

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Bioactivity evaluation of cudraxanthone I, neocyclomorusin and (9 beta h)-3 beta-acetoxylanosta-7,24-diene isolated from Milicia excelsa Welw. C. C. Berg (Moraceae)</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="p">MEDICINAL CHEMISTRY RESEARCH</subfield>
    <subfield code="v">25</subfield>
    <subfield code="n">10</subfield>
    <subfield code="c">2250-2257</subfield>
  </datafield>
  <controlfield tag="001">55093</controlfield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">This study aimed to investigate the cytotoxic, antioxidant, and antimicrobial activities of three compounds isolated from the methanolic extract of the roots bark of Milicia excelsa (Moraceace) namely cudraxanthone I (1), neocyclomorusin (2) and (9 beta H)-3 beta-acetoxylanosta-7,24-diene (3). The cytotoxic activities of the compounds were determined using the xCELLigence system (Real Time Cell Analyzer). The compounds of cudraxanthone I and neocyclomorusin exhibited the excellent cytotoxic effects on the growth of human cervical epithelioid carcinoma (HeLa) cell lines (IC50 &amp;lt; 10 A mu g/mL). Among the compounds; neocyclomorusin showed the highest radical scavenging activity (IC50 = 0.73 A +/- 0.01 mg/mL). The compounds exhibited low antimicrobial activity against Staphylococcus aureus ATCC 25923. This study supports the documented medicinal effects of the compounds and opens up the possibilities of pharmaceutical applications.</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="2">opendefinition.org</subfield>
    <subfield code="a">cc-by</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Univ Yaounde I, Dept Chem, Higher Teacher Training Coll, POB 47, Yaounde, Cameroon</subfield>
    <subfield code="a">Kapche, Gilbert D. W. F.</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Univ Yaounde I, Dept Organ Chem, Fac Sci, POB 812, Yaounde, Cameroon</subfield>
    <subfield code="a">Ouete, Judith L. Nantchouang</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Cankiri Karatekin Univ, Dept Chem, Fac Sci, Cankiri, Turkey</subfield>
    <subfield code="a">Demirtas, Ibrahim</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Cankiri Karatekin Univ, Dept Chem, Fac Sci, Cankiri, Turkey</subfield>
    <subfield code="a">Koc, Merve B.</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Univ Yaounde I, Dept Organ Chem, Fac Sci, POB 812, Yaounde, Cameroon</subfield>
    <subfield code="a">Ngadjui, Bonaventure T.</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="b">article</subfield>
    <subfield code="a">publication</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="u">Gazi Univ, Dept Biol, Fac Sci, TR-06500 Ankara, Turkey</subfield>
    <subfield code="a">Oke-Altuntas, Feyza</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2016-01-01</subfield>
  </datafield>
  <controlfield tag="005">20210315234626.0</controlfield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="o">oai:zenodo.org:55093</subfield>
    <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="z">md5:165c4c8f3e01ec32b5c8f58dbd2da570</subfield>
    <subfield code="s">299</subfield>
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/55093/files/bib-40957b9a-b7a6-4380-95b3-aed0d82aea31.txt</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield>
    <subfield code="a">Creative Commons Attribution</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.1007/s00044-016-1670-3</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
</record>