1 Ocak 2016 Dergi makalesi Açık Erişim

Oke-Altuntas, Feyza; Kapche, Gilbert D. W. F.; Ouete, Judith L. Nantchouang; Demirtas, Ibrahim; Koc, Merve B.; Ngadjui, Bonaventure T.

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  <dc:creator>Oke-Altuntas, Feyza</dc:creator>
  <dc:creator>Kapche, Gilbert D. W. F.</dc:creator>
  <dc:creator>Ouete, Judith L. Nantchouang</dc:creator>
  <dc:creator>Demirtas, Ibrahim</dc:creator>
  <dc:creator>Koc, Merve B.</dc:creator>
  <dc:creator>Ngadjui, Bonaventure T.</dc:creator>
  <dc:date>2016-01-01</dc:date>
  <dc:description>This study aimed to investigate the cytotoxic, antioxidant, and antimicrobial activities of three compounds isolated from the methanolic extract of the roots bark of Milicia excelsa (Moraceace) namely cudraxanthone I (1), neocyclomorusin (2) and (9 beta H)-3 beta-acetoxylanosta-7,24-diene (3). The cytotoxic activities of the compounds were determined using the xCELLigence system (Real Time Cell Analyzer). The compounds of cudraxanthone I and neocyclomorusin exhibited the excellent cytotoxic effects on the growth of human cervical epithelioid carcinoma (HeLa) cell lines (IC50 &lt; 10 A mu g/mL). Among the compounds; neocyclomorusin showed the highest radical scavenging activity (IC50 = 0.73 A +/- 0.01 mg/mL). The compounds exhibited low antimicrobial activity against Staphylococcus aureus ATCC 25923. This study supports the documented medicinal effects of the compounds and opens up the possibilities of pharmaceutical applications.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/55093</dc:identifier>
  <dc:identifier>oai:zenodo.org:55093</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>MEDICINAL CHEMISTRY RESEARCH 25(10) 2250-2257</dc:source>
  <dc:title>Bioactivity evaluation of cudraxanthone I, neocyclomorusin and (9 beta h)-3 beta-acetoxylanosta-7,24-diene isolated from Milicia excelsa Welw. C. C. Berg (Moraceae)</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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