1 Ocak 2016 Dergi makalesi Açık Erişim

Oke-Altuntas, Feyza; Kapche, Gilbert D. W. F.; Ouete, Judith L. Nantchouang; Demirtas, Ibrahim; Koc, Merve B.; Ngadjui, Bonaventure T.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/55093</identifier>
  <creators>
    <creator>
      <creatorName>Oke-Altuntas, Feyza</creatorName>
      <givenName>Feyza</givenName>
      <familyName>Oke-Altuntas</familyName>
      <affiliation>Gazi Univ, Dept Biol, Fac Sci, TR-06500 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kapche, Gilbert D. W. F.</creatorName>
      <givenName>Gilbert D. W. F.</givenName>
      <familyName>Kapche</familyName>
      <affiliation>Univ Yaounde I, Dept Chem, Higher Teacher Training Coll, POB 47, Yaounde, Cameroon</affiliation>
    </creator>
    <creator>
      <creatorName>Ouete, Judith L. Nantchouang</creatorName>
      <givenName>Judith L. Nantchouang</givenName>
      <familyName>Ouete</familyName>
      <affiliation>Univ Yaounde I, Dept Organ Chem, Fac Sci, POB 812, Yaounde, Cameroon</affiliation>
    </creator>
    <creator>
      <creatorName>Demirtas, Ibrahim</creatorName>
      <givenName>Ibrahim</givenName>
      <familyName>Demirtas</familyName>
      <affiliation>Cankiri Karatekin Univ, Dept Chem, Fac Sci, Cankiri, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Koc, Merve B.</creatorName>
      <givenName>Merve B.</givenName>
      <familyName>Koc</familyName>
      <affiliation>Cankiri Karatekin Univ, Dept Chem, Fac Sci, Cankiri, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ngadjui, Bonaventure T.</creatorName>
      <givenName>Bonaventure T.</givenName>
      <familyName>Ngadjui</familyName>
      <affiliation>Univ Yaounde I, Dept Organ Chem, Fac Sci, POB 812, Yaounde, Cameroon</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Bioactivity Evaluation Of Cudraxanthone I, Neocyclomorusin And (9 Beta H)-3 Beta-Acetoxylanosta-7,24-Diene Isolated From Milicia Excelsa Welw. C. C. Berg (Moraceae)</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2016</publicationYear>
  <dates>
    <date dateType="Issued">2016-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/55093</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s00044-016-1670-3</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">This study aimed to investigate the cytotoxic, antioxidant, and antimicrobial activities of three compounds isolated from the methanolic extract of the roots bark of Milicia excelsa (Moraceace) namely cudraxanthone I (1), neocyclomorusin (2) and (9 beta H)-3 beta-acetoxylanosta-7,24-diene (3). The cytotoxic activities of the compounds were determined using the xCELLigence system (Real Time Cell Analyzer). The compounds of cudraxanthone I and neocyclomorusin exhibited the excellent cytotoxic effects on the growth of human cervical epithelioid carcinoma (HeLa) cell lines (IC50 &amp;lt; 10 A mu g/mL). Among the compounds; neocyclomorusin showed the highest radical scavenging activity (IC50 = 0.73 A +/- 0.01 mg/mL). The compounds exhibited low antimicrobial activity against Staphylococcus aureus ATCC 25923. This study supports the documented medicinal effects of the compounds and opens up the possibilities of pharmaceutical applications.</description>
  </descriptions>
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