1 Ocak 2016 Dergi makalesi Açık Erişim

Oke-Altuntas, Feyza; Kapche, Gilbert D. W. F.; Ouete, Judith L. Nantchouang; Demirtas, Ibrahim; Koc, Merve B.; Ngadjui, Bonaventure T.

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{
  "@context": "https://schema.org/", 
  "@id": 55093, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Gazi Univ, Dept Biol, Fac Sci, TR-06500 Ankara, Turkey", 
      "name": "Oke-Altuntas, Feyza"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Yaounde I, Dept Chem, Higher Teacher Training Coll, POB 47, Yaounde, Cameroon", 
      "name": "Kapche, Gilbert D. W. F."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Yaounde I, Dept Organ Chem, Fac Sci, POB 812, Yaounde, Cameroon", 
      "name": "Ouete, Judith L. Nantchouang"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Cankiri Karatekin Univ, Dept Chem, Fac Sci, Cankiri, Turkey", 
      "name": "Demirtas, Ibrahim"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Cankiri Karatekin Univ, Dept Chem, Fac Sci, Cankiri, Turkey", 
      "name": "Koc, Merve B."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Yaounde I, Dept Organ Chem, Fac Sci, POB 812, Yaounde, Cameroon", 
      "name": "Ngadjui, Bonaventure T."
    }
  ], 
  "datePublished": "2016-01-01", 
  "description": "This study aimed to investigate the cytotoxic, antioxidant, and antimicrobial activities of three compounds isolated from the methanolic extract of the roots bark of Milicia excelsa (Moraceace) namely cudraxanthone I (1), neocyclomorusin (2) and (9 beta H)-3 beta-acetoxylanosta-7,24-diene (3). The cytotoxic activities of the compounds were determined using the xCELLigence system (Real Time Cell Analyzer). The compounds of cudraxanthone I and neocyclomorusin exhibited the excellent cytotoxic effects on the growth of human cervical epithelioid carcinoma (HeLa) cell lines (IC50 < 10 A mu g/mL). Among the compounds; neocyclomorusin showed the highest radical scavenging activity (IC50 = 0.73 A +/- 0.01 mg/mL). The compounds exhibited low antimicrobial activity against Staphylococcus aureus ATCC 25923. This study supports the documented medicinal effects of the compounds and opens up the possibilities of pharmaceutical applications.", 
  "headline": "Bioactivity evaluation of cudraxanthone I, neocyclomorusin and (9 beta h)-3 beta-acetoxylanosta-7,24-diene isolated from Milicia excelsa Welw. C. C. Berg (Moraceae)", 
  "identifier": 55093, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Bioactivity evaluation of cudraxanthone I, neocyclomorusin and (9 beta h)-3 beta-acetoxylanosta-7,24-diene isolated from Milicia excelsa Welw. C. C. Berg (Moraceae)", 
  "url": "https://aperta.ulakbim.gov.tr/record/55093"
}