1 Ocak 2016 Dergi makalesi Açık Erişim

Oke-Altuntas, Feyza; Kapche, Gilbert D. W. F.; Ouete, Judith L. Nantchouang; Demirtas, Ibrahim; Koc, Merve B.; Ngadjui, Bonaventure T.

JSON

{
  "conceptrecid": "55092", 
  "created": "2021-03-15T23:46:26.895943+00:00", 
  "doi": "10.1007/s00044-016-1670-3", 
  "files": [
    {
      "bucket": "e8c8ece1-ccea-4eca-a2e8-c1605a8d808c", 
      "checksum": "md5:165c4c8f3e01ec32b5c8f58dbd2da570", 
      "key": "bib-40957b9a-b7a6-4380-95b3-aed0d82aea31.txt", 
      "links": {
        "self": "https://aperta.ulakbim.gov.tr/api/files/e8c8ece1-ccea-4eca-a2e8-c1605a8d808c/bib-40957b9a-b7a6-4380-95b3-aed0d82aea31.txt"
      }, 
      "size": 299, 
      "type": "txt"
    }
  ], 
  "id": 55093, 
  "links": {
    "badge": "https://aperta.ulakbim.gov.tr/badge/doi/10.1007/s00044-016-1670-3.svg", 
    "bucket": "https://aperta.ulakbim.gov.tr/api/files/e8c8ece1-ccea-4eca-a2e8-c1605a8d808c", 
    "doi": "https://doi.org/10.1007/s00044-016-1670-3", 
    "html": "https://aperta.ulakbim.gov.tr/record/55093", 
    "latest": "https://aperta.ulakbim.gov.tr/api/records/55093", 
    "latest_html": "https://aperta.ulakbim.gov.tr/record/55093"
  }, 
  "metadata": {
    "access_right": "open", 
    "access_right_category": "success", 
    "communities": [
      {
        "id": "tubitak-destekli-proje-yayinlari"
      }
    ], 
    "creators": [
      {
        "affiliation": "Gazi Univ, Dept Biol, Fac Sci, TR-06500 Ankara, Turkey", 
        "name": "Oke-Altuntas, Feyza"
      }, 
      {
        "affiliation": "Univ Yaounde I, Dept Chem, Higher Teacher Training Coll, POB 47, Yaounde, Cameroon", 
        "name": "Kapche, Gilbert D. W. F."
      }, 
      {
        "affiliation": "Univ Yaounde I, Dept Organ Chem, Fac Sci, POB 812, Yaounde, Cameroon", 
        "name": "Ouete, Judith L. Nantchouang"
      }, 
      {
        "affiliation": "Cankiri Karatekin Univ, Dept Chem, Fac Sci, Cankiri, Turkey", 
        "name": "Demirtas, Ibrahim"
      }, 
      {
        "affiliation": "Cankiri Karatekin Univ, Dept Chem, Fac Sci, Cankiri, Turkey", 
        "name": "Koc, Merve B."
      }, 
      {
        "affiliation": "Univ Yaounde I, Dept Organ Chem, Fac Sci, POB 812, Yaounde, Cameroon", 
        "name": "Ngadjui, Bonaventure T."
      }
    ], 
    "description": "This study aimed to investigate the cytotoxic, antioxidant, and antimicrobial activities of three compounds isolated from the methanolic extract of the roots bark of Milicia excelsa (Moraceace) namely cudraxanthone I (1), neocyclomorusin (2) and (9 beta H)-3 beta-acetoxylanosta-7,24-diene (3). The cytotoxic activities of the compounds were determined using the xCELLigence system (Real Time Cell Analyzer). The compounds of cudraxanthone I and neocyclomorusin exhibited the excellent cytotoxic effects on the growth of human cervical epithelioid carcinoma (HeLa) cell lines (IC50 < 10 A mu g/mL). Among the compounds; neocyclomorusin showed the highest radical scavenging activity (IC50 = 0.73 A +/- 0.01 mg/mL). The compounds exhibited low antimicrobial activity against Staphylococcus aureus ATCC 25923. This study supports the documented medicinal effects of the compounds and opens up the possibilities of pharmaceutical applications.", 
    "doi": "10.1007/s00044-016-1670-3", 
    "has_grant": false, 
    "journal": {
      "issue": "10", 
      "pages": "2250-2257", 
      "title": "MEDICINAL CHEMISTRY RESEARCH", 
      "volume": "25"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2016-01-01", 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "55093"
          }, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "55092"
          }
        }
      ]
    }, 
    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
    }, 
    "title": "Bioactivity evaluation of cudraxanthone I, neocyclomorusin and (9 beta h)-3 beta-acetoxylanosta-7,24-diene isolated from Milicia excelsa Welw. C. C. Berg (Moraceae)"
  }, 
  "owners": [
    1
  ], 
  "revision": 1, 
  "stats": {
    "downloads": 6.0, 
    "unique_downloads": 6.0, 
    "unique_views": 30.0, 
    "version_downloads": 6.0, 
    "version_unique_downloads": 6.0, 
    "version_unique_views": 30.0, 
    "version_views": 30.0, 
    "version_volume": 1794.0, 
    "views": 30.0, 
    "volume": 1794.0
  }, 
  "updated": "2021-03-15T23:46:26.939233+00:00"
}