1 Ocak 2016 Dergi makalesi Açık Erişim

Oke-Altuntas, Feyza; Kapche, Gilbert D. W. F.; Ouete, Judith L. Nantchouang; Demirtas, Ibrahim; Koc, Merve B.; Ngadjui, Bonaventure T.

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    "creators": [
      {
        "affiliation": "Gazi Univ, Dept Biol, Fac Sci, TR-06500 Ankara, Turkey", 
        "name": "Oke-Altuntas, Feyza"
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      {
        "affiliation": "Univ Yaounde I, Dept Chem, Higher Teacher Training Coll, POB 47, Yaounde, Cameroon", 
        "name": "Kapche, Gilbert D. W. F."
      }, 
      {
        "affiliation": "Univ Yaounde I, Dept Organ Chem, Fac Sci, POB 812, Yaounde, Cameroon", 
        "name": "Ouete, Judith L. Nantchouang"
      }, 
      {
        "affiliation": "Cankiri Karatekin Univ, Dept Chem, Fac Sci, Cankiri, Turkey", 
        "name": "Demirtas, Ibrahim"
      }, 
      {
        "affiliation": "Cankiri Karatekin Univ, Dept Chem, Fac Sci, Cankiri, Turkey", 
        "name": "Koc, Merve B."
      }, 
      {
        "affiliation": "Univ Yaounde I, Dept Organ Chem, Fac Sci, POB 812, Yaounde, Cameroon", 
        "name": "Ngadjui, Bonaventure T."
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    "description": "This study aimed to investigate the cytotoxic, antioxidant, and antimicrobial activities of three compounds isolated from the methanolic extract of the roots bark of Milicia excelsa (Moraceace) namely cudraxanthone I (1), neocyclomorusin (2) and (9 beta H)-3 beta-acetoxylanosta-7,24-diene (3). The cytotoxic activities of the compounds were determined using the xCELLigence system (Real Time Cell Analyzer). The compounds of cudraxanthone I and neocyclomorusin exhibited the excellent cytotoxic effects on the growth of human cervical epithelioid carcinoma (HeLa) cell lines (IC50 < 10 A mu g/mL). Among the compounds; neocyclomorusin showed the highest radical scavenging activity (IC50 = 0.73 A +/- 0.01 mg/mL). The compounds exhibited low antimicrobial activity against Staphylococcus aureus ATCC 25923. This study supports the documented medicinal effects of the compounds and opens up the possibilities of pharmaceutical applications.", 
    "doi": "10.1007/s00044-016-1670-3", 
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    "journal": {
      "issue": "10", 
      "pages": "2250-2257", 
      "title": "MEDICINAL CHEMISTRY RESEARCH", 
      "volume": "25"
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    "license": {
      "id": "cc-by"
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    "publication_date": "2016-01-01", 
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    "title": "Bioactivity evaluation of cudraxanthone I, neocyclomorusin and (9 beta h)-3 beta-acetoxylanosta-7,24-diene isolated from Milicia excelsa Welw. C. C. Berg (Moraceae)"
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