1 Ocak 2016 Dergi makalesi Açık Erişim

Oke-Altuntas, Feyza; Kapche, Gilbert D. W. F.; Ouete, Judith L. Nantchouang; Demirtas, Ibrahim; Koc, Merve B.; Ngadjui, Bonaventure T.

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{
  "DOI": "10.1007/s00044-016-1670-3", 
  "abstract": "This study aimed to investigate the cytotoxic, antioxidant, and antimicrobial activities of three compounds isolated from the methanolic extract of the roots bark of Milicia excelsa (Moraceace) namely cudraxanthone I (1), neocyclomorusin (2) and (9 beta H)-3 beta-acetoxylanosta-7,24-diene (3). The cytotoxic activities of the compounds were determined using the xCELLigence system (Real Time Cell Analyzer). The compounds of cudraxanthone I and neocyclomorusin exhibited the excellent cytotoxic effects on the growth of human cervical epithelioid carcinoma (HeLa) cell lines (IC50 < 10 A mu g/mL). Among the compounds; neocyclomorusin showed the highest radical scavenging activity (IC50 = 0.73 A +/- 0.01 mg/mL). The compounds exhibited low antimicrobial activity against Staphylococcus aureus ATCC 25923. This study supports the documented medicinal effects of the compounds and opens up the possibilities of pharmaceutical applications.", 
  "author": [
    {
      "family": "Oke-Altuntas", 
      "given": " Feyza"
    }, 
    {
      "family": "Kapche", 
      "given": " Gilbert D. W. F."
    }, 
    {
      "family": "Ouete", 
      "given": " Judith L. Nantchouang"
    }, 
    {
      "family": "Demirtas", 
      "given": " Ibrahim"
    }, 
    {
      "family": "Koc", 
      "given": " Merve B."
    }, 
    {
      "family": "Ngadjui", 
      "given": " Bonaventure T."
    }
  ], 
  "container_title": "MEDICINAL CHEMISTRY RESEARCH", 
  "id": "55093", 
  "issue": "10", 
  "issued": {
    "date-parts": [
      [
        2016, 
        1, 
        1
      ]
    ]
  }, 
  "page": "2250-2257", 
  "title": "Bioactivity evaluation of cudraxanthone I, neocyclomorusin and (9 beta h)-3 beta-acetoxylanosta-7,24-diene isolated from Milicia excelsa Welw. C. C. Berg (Moraceae)", 
  "type": "article-journal", 
  "volume": "25"
}