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Nanoengineering InP Quantum Dot-Based Photoactive Biointerfaces for Optical Control of Neurons

Karatum, Onuralp; Aria, Mohammad Mohammadi; Eren, Guncem Ozgun; Yildiz, Erdost; Melikov, Rustamzhon; Srivastava, Shashi Bhushan; Surme, Saliha; Dogru, Itir Bakis; Jalali, Houman Bahmani; Ulgut, Burak; Sahin, Afsun; Kavakli, Ibrahim Halil; Nizamoglu, Sedat

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<oai_dc:dc xmlns:dc="" xmlns:oai_dc="" xmlns:xsi="" xsi:schemaLocation="">
  <dc:creator>Karatum, Onuralp</dc:creator>
  <dc:creator>Aria, Mohammad Mohammadi</dc:creator>
  <dc:creator>Eren, Guncem Ozgun</dc:creator>
  <dc:creator>Yildiz, Erdost</dc:creator>
  <dc:creator>Melikov, Rustamzhon</dc:creator>
  <dc:creator>Srivastava, Shashi Bhushan</dc:creator>
  <dc:creator>Surme, Saliha</dc:creator>
  <dc:creator>Dogru, Itir Bakis</dc:creator>
  <dc:creator>Jalali, Houman Bahmani</dc:creator>
  <dc:creator>Ulgut, Burak</dc:creator>
  <dc:creator>Sahin, Afsun</dc:creator>
  <dc:creator>Kavakli, Ibrahim Halil</dc:creator>
  <dc:creator>Nizamoglu, Sedat</dc:creator>
  <dc:description>Light-activated biointerfaces provide a non-genetic route for effective control of neural activity. InP quantum dots (QDs) have a high potential for such biomedical applications due to their uniquely tunable electronic properties, photostability, toxic-heavy-metal-free content, heterostructuring, and solution-processing ability. However, the effect of QD nanostructure and biointerface architecture on the photoelectrical cellular interfacing remained unexplored. Here, we unravel the control of the photoelectrical response of InP QD-based biointerfaces via nanoengineering from QD to device-level. At QD level, thin ZnS shell growth (similar to 0.65 nm) enhances the current level of biointerfaces over an order of magnitude with respect to only InP core QDs. At device-level, band alignment engineering allows for the bidirectional photoelectrochemical current generation, which enables light-induced temporally precise and rapidly reversible action potential generation and hyperpolarization on primary hippocampal neurons. Our findings show that nanoengineering QD-based biointerfaces hold great promise for next-generation neurostimulation devices.</dc:description>
  <dc:source>FRONTIERS IN NEUROSCIENCE 15</dc:source>
  <dc:title>Nanoengineering InP Quantum Dot-Based Photoactive Biointerfaces for Optical Control of Neurons</dc:title>
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