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Nanoengineering InP Quantum Dot-Based Photoactive Biointerfaces for Optical Control of Neurons

Karatum, Onuralp; Aria, Mohammad Mohammadi; Eren, Guncem Ozgun; Yildiz, Erdost; Melikov, Rustamzhon; Srivastava, Shashi Bhushan; Surme, Saliha; Dogru, Itir Bakis; Jalali, Houman Bahmani; Ulgut, Burak; Sahin, Afsun; Kavakli, Ibrahim Halil; Nizamoglu, Sedat


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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Karatum, Onuralp</dc:creator>
  <dc:creator>Aria, Mohammad Mohammadi</dc:creator>
  <dc:creator>Eren, Guncem Ozgun</dc:creator>
  <dc:creator>Yildiz, Erdost</dc:creator>
  <dc:creator>Melikov, Rustamzhon</dc:creator>
  <dc:creator>Srivastava, Shashi Bhushan</dc:creator>
  <dc:creator>Surme, Saliha</dc:creator>
  <dc:creator>Dogru, Itir Bakis</dc:creator>
  <dc:creator>Jalali, Houman Bahmani</dc:creator>
  <dc:creator>Ulgut, Burak</dc:creator>
  <dc:creator>Sahin, Afsun</dc:creator>
  <dc:creator>Kavakli, Ibrahim Halil</dc:creator>
  <dc:creator>Nizamoglu, Sedat</dc:creator>
  <dc:date>2021-01-01</dc:date>
  <dc:description>Light-activated biointerfaces provide a non-genetic route for effective control of neural activity. InP quantum dots (QDs) have a high potential for such biomedical applications due to their uniquely tunable electronic properties, photostability, toxic-heavy-metal-free content, heterostructuring, and solution-processing ability. However, the effect of QD nanostructure and biointerface architecture on the photoelectrical cellular interfacing remained unexplored. Here, we unravel the control of the photoelectrical response of InP QD-based biointerfaces via nanoengineering from QD to device-level. At QD level, thin ZnS shell growth (similar to 0.65 nm) enhances the current level of biointerfaces over an order of magnitude with respect to only InP core QDs. At device-level, band alignment engineering allows for the bidirectional photoelectrochemical current generation, which enables light-induced temporally precise and rapidly reversible action potential generation and hyperpolarization on primary hippocampal neurons. Our findings show that nanoengineering QD-based biointerfaces hold great promise for next-generation neurostimulation devices.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/239512</dc:identifier>
  <dc:identifier>oai:aperta.ulakbim.gov.tr:239512</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>FRONTIERS IN NEUROSCIENCE 15</dc:source>
  <dc:title>Nanoengineering InP Quantum Dot-Based Photoactive Biointerfaces for Optical Control of Neurons</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>
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