Dergi makalesi Açık Erişim

Nanoengineering InP Quantum Dot-Based Photoactive Biointerfaces for Optical Control of Neurons

Karatum, Onuralp; Aria, Mohammad Mohammadi; Eren, Guncem Ozgun; Yildiz, Erdost; Melikov, Rustamzhon; Srivastava, Shashi Bhushan; Surme, Saliha; Dogru, Itir Bakis; Jalali, Houman Bahmani; Ulgut, Burak; Sahin, Afsun; Kavakli, Ibrahim Halil; Nizamoglu, Sedat


JSON

{
  "conceptrecid": "239511", 
  "created": "2022-10-07T10:35:57.170431+00:00", 
  "doi": "10.3389/fnins.2021.652608", 
  "files": [
    {
      "bucket": "5c989b67-91e9-43a2-a16c-937e98735b4e", 
      "checksum": "md5:bb506c414fc1ded57ed3d3e0a27cc6ab", 
      "key": "bib-918a7dd0-ed52-4063-bd75-1b8e1b6553de.txt", 
      "links": {
        "self": "https://aperta.ulakbim.gov.tr/api/files/5c989b67-91e9-43a2-a16c-937e98735b4e/bib-918a7dd0-ed52-4063-bd75-1b8e1b6553de.txt"
      }, 
      "size": 298, 
      "type": "txt"
    }
  ], 
  "id": 239512, 
  "links": {
    "badge": "https://aperta.ulakbim.gov.tr/badge/doi/10.3389/fnins.2021.652608.svg", 
    "bucket": "https://aperta.ulakbim.gov.tr/api/files/5c989b67-91e9-43a2-a16c-937e98735b4e", 
    "doi": "https://doi.org/10.3389/fnins.2021.652608", 
    "html": "https://aperta.ulakbim.gov.tr/record/239512", 
    "latest": "https://aperta.ulakbim.gov.tr/api/records/239512", 
    "latest_html": "https://aperta.ulakbim.gov.tr/record/239512"
  }, 
  "metadata": {
    "access_right": "open", 
    "access_right_category": "success", 
    "communities": [
      {
        "id": "tubitak-destekli-proje-yayinlari"
      }
    ], 
    "creators": [
      {
        "affiliation": "Koc Univ, Dept Elect & Elect Engn, Istanbul, Turkey", 
        "name": "Karatum, Onuralp"
      }, 
      {
        "affiliation": "Koc Univ, Dept Biomed Sci & Engn, Istanbul, Turkey", 
        "name": "Aria, Mohammad Mohammadi"
      }, 
      {
        "affiliation": "Koc Univ, Dept Biomed Sci & Engn, Istanbul, Turkey", 
        "name": "Eren, Guncem Ozgun"
      }, 
      {
        "affiliation": "Koc Univ, Res Ctr Translat Med, Istanbul, Turkey", 
        "name": "Yildiz, Erdost"
      }, 
      {
        "affiliation": "Koc Univ, Dept Elect & Elect Engn, Istanbul, Turkey", 
        "name": "Melikov, Rustamzhon"
      }, 
      {
        "affiliation": "Koc Univ, Dept Elect & Elect Engn, Istanbul, Turkey", 
        "name": "Srivastava, Shashi Bhushan"
      }, 
      {
        "affiliation": "Koc Univ, Dept Mol Biol & Genet, Istanbul, Turkey", 
        "name": "Surme, Saliha"
      }, 
      {
        "affiliation": "Koc Univ, Dept Biomed Sci & Engn, Istanbul, Turkey", 
        "name": "Dogru, Itir Bakis"
      }, 
      {
        "affiliation": "Koc Univ, Dept Biomed Sci & Engn, Istanbul, Turkey", 
        "name": "Jalali, Houman Bahmani"
      }, 
      {
        "affiliation": "Brikent Univ, Dept Chem, Ankara, Turkey", 
        "name": "Ulgut, Burak"
      }, 
      {
        "name": "Sahin, Afsun"
      }, 
      {
        "affiliation": "Koc Univ, Dept Mol Biol & Genet, Istanbul, Turkey", 
        "name": "Kavakli, Ibrahim Halil"
      }, 
      {
        "name": "Nizamoglu, Sedat"
      }
    ], 
    "description": "Light-activated biointerfaces provide a non-genetic route for effective control of neural activity. InP quantum dots (QDs) have a high potential for such biomedical applications due to their uniquely tunable electronic properties, photostability, toxic-heavy-metal-free content, heterostructuring, and solution-processing ability. However, the effect of QD nanostructure and biointerface architecture on the photoelectrical cellular interfacing remained unexplored. Here, we unravel the control of the photoelectrical response of InP QD-based biointerfaces via nanoengineering from QD to device-level. At QD level, thin ZnS shell growth (similar to 0.65 nm) enhances the current level of biointerfaces over an order of magnitude with respect to only InP core QDs. At device-level, band alignment engineering allows for the bidirectional photoelectrochemical current generation, which enables light-induced temporally precise and rapidly reversible action potential generation and hyperpolarization on primary hippocampal neurons. Our findings show that nanoengineering QD-based biointerfaces hold great promise for next-generation neurostimulation devices.", 
    "doi": "10.3389/fnins.2021.652608", 
    "has_grant": false, 
    "journal": {
      "title": "FRONTIERS IN NEUROSCIENCE", 
      "volume": "15"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2021-01-01", 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "239512"
          }, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "239511"
          }
        }
      ]
    }, 
    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
    }, 
    "science_branches": [
      "Di\u011fer"
    ], 
    "title": "Nanoengineering InP Quantum Dot-Based Photoactive Biointerfaces for Optical Control of Neurons"
  }, 
  "owners": [
    1
  ], 
  "revision": 1, 
  "stats": {
    "downloads": 7.0, 
    "unique_downloads": 7.0, 
    "unique_views": 72.0, 
    "version_downloads": 7.0, 
    "version_unique_downloads": 7.0, 
    "version_unique_views": 72.0, 
    "version_views": 84.0, 
    "version_volume": 2086.0, 
    "views": 84.0, 
    "volume": 2086.0
  }, 
  "updated": "2022-10-07T10:35:57.225887+00:00"
}
84
7
görüntülenme
indirilme
Görüntülenme 84
İndirme 7
Veri hacmi 2.1 kB
Tekil görüntülenme 72
Tekil indirme 7

Alıntı yap