Dergi makalesi Açık Erişim
Karatum, Onuralp; Aria, Mohammad Mohammadi; Eren, Guncem Ozgun; Yildiz, Erdost; Melikov, Rustamzhon; Srivastava, Shashi Bhushan; Surme, Saliha; Dogru, Itir Bakis; Jalali, Houman Bahmani; Ulgut, Burak; Sahin, Afsun; Kavakli, Ibrahim Halil; Nizamoglu, Sedat
{ "DOI": "10.3389/fnins.2021.652608", "abstract": "Light-activated biointerfaces provide a non-genetic route for effective control of neural activity. InP quantum dots (QDs) have a high potential for such biomedical applications due to their uniquely tunable electronic properties, photostability, toxic-heavy-metal-free content, heterostructuring, and solution-processing ability. However, the effect of QD nanostructure and biointerface architecture on the photoelectrical cellular interfacing remained unexplored. Here, we unravel the control of the photoelectrical response of InP QD-based biointerfaces via nanoengineering from QD to device-level. At QD level, thin ZnS shell growth (similar to 0.65 nm) enhances the current level of biointerfaces over an order of magnitude with respect to only InP core QDs. At device-level, band alignment engineering allows for the bidirectional photoelectrochemical current generation, which enables light-induced temporally precise and rapidly reversible action potential generation and hyperpolarization on primary hippocampal neurons. Our findings show that nanoengineering QD-based biointerfaces hold great promise for next-generation neurostimulation devices.", "author": [ { "family": "Karatum", "given": " Onuralp" }, { "family": "Aria", "given": " Mohammad Mohammadi" }, { "family": "Eren", "given": " Guncem Ozgun" }, { "family": "Yildiz", "given": " Erdost" }, { "family": "Melikov", "given": " Rustamzhon" }, { "family": "Srivastava", "given": " Shashi Bhushan" }, { "family": "Surme", "given": " Saliha" }, { "family": "Dogru", "given": " Itir Bakis" }, { "family": "Jalali", "given": " Houman Bahmani" }, { "family": "Ulgut", "given": " Burak" }, { "family": "Sahin", "given": " Afsun" }, { "family": "Kavakli", "given": " Ibrahim Halil" }, { "family": "Nizamoglu", "given": " Sedat" } ], "container_title": "FRONTIERS IN NEUROSCIENCE", "id": "239512", "issued": { "date-parts": [ [ 2021, 1, 1 ] ] }, "title": "Nanoengineering InP Quantum Dot-Based Photoactive Biointerfaces for Optical Control of Neurons", "type": "article-journal", "volume": "15" }
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