1 Ocak 2021 Dergi makalesi Açık Erişim

Karatum, Onuralp; Aria, Mohammad Mohammadi; Eren, Guncem Ozgun; Yildiz, Erdost; Melikov, Rustamzhon; Srivastava, Shashi Bhushan; Surme, Saliha; Dogru, Itir Bakis; Jalali, Houman Bahmani; Ulgut, Burak; Sahin, Afsun; Kavakli, Ibrahim Halil; Nizamoglu, Sedat

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{
  "DOI": "10.3389/fnins.2021.652608", 
  "abstract": "Light-activated biointerfaces provide a non-genetic route for effective control of neural activity. InP quantum dots (QDs) have a high potential for such biomedical applications due to their uniquely tunable electronic properties, photostability, toxic-heavy-metal-free content, heterostructuring, and solution-processing ability. However, the effect of QD nanostructure and biointerface architecture on the photoelectrical cellular interfacing remained unexplored. Here, we unravel the control of the photoelectrical response of InP QD-based biointerfaces via nanoengineering from QD to device-level. At QD level, thin ZnS shell growth (similar to 0.65 nm) enhances the current level of biointerfaces over an order of magnitude with respect to only InP core QDs. At device-level, band alignment engineering allows for the bidirectional photoelectrochemical current generation, which enables light-induced temporally precise and rapidly reversible action potential generation and hyperpolarization on primary hippocampal neurons. Our findings show that nanoengineering QD-based biointerfaces hold great promise for next-generation neurostimulation devices.", 
  "author": [
    {
      "family": "Karatum", 
      "given": " Onuralp"
    }, 
    {
      "family": "Aria", 
      "given": " Mohammad Mohammadi"
    }, 
    {
      "family": "Eren", 
      "given": " Guncem Ozgun"
    }, 
    {
      "family": "Yildiz", 
      "given": " Erdost"
    }, 
    {
      "family": "Melikov", 
      "given": " Rustamzhon"
    }, 
    {
      "family": "Srivastava", 
      "given": " Shashi Bhushan"
    }, 
    {
      "family": "Surme", 
      "given": " Saliha"
    }, 
    {
      "family": "Dogru", 
      "given": " Itir Bakis"
    }, 
    {
      "family": "Jalali", 
      "given": " Houman Bahmani"
    }, 
    {
      "family": "Ulgut", 
      "given": " Burak"
    }, 
    {
      "family": "Sahin", 
      "given": " Afsun"
    }, 
    {
      "family": "Kavakli", 
      "given": " Ibrahim Halil"
    }, 
    {
      "family": "Nizamoglu", 
      "given": " Sedat"
    }
  ], 
  "container_title": "FRONTIERS IN NEUROSCIENCE", 
  "id": "239512", 
  "issued": {
    "date-parts": [
      [
        2021, 
        1, 
        1
      ]
    ]
  }, 
  "title": "Nanoengineering InP Quantum Dot-Based Photoactive Biointerfaces for Optical Control of Neurons", 
  "type": "article-journal", 
  "volume": "15"
}