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Nanoengineering InP Quantum Dot-Based Photoactive Biointerfaces for Optical Control of Neurons

Karatum, Onuralp; Aria, Mohammad Mohammadi; Eren, Guncem Ozgun; Yildiz, Erdost; Melikov, Rustamzhon; Srivastava, Shashi Bhushan; Surme, Saliha; Dogru, Itir Bakis; Jalali, Houman Bahmani; Ulgut, Burak; Sahin, Afsun; Kavakli, Ibrahim Halil; Nizamoglu, Sedat


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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/239512</identifier>
  <creators>
    <creator>
      <creatorName>Karatum, Onuralp</creatorName>
      <givenName>Onuralp</givenName>
      <familyName>Karatum</familyName>
      <affiliation>Koc Univ, Dept Elect &amp; Elect Engn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Aria, Mohammad Mohammadi</creatorName>
      <givenName>Mohammad Mohammadi</givenName>
      <familyName>Aria</familyName>
      <affiliation>Koc Univ, Dept Biomed Sci &amp; Engn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Eren, Guncem Ozgun</creatorName>
      <givenName>Guncem Ozgun</givenName>
      <familyName>Eren</familyName>
      <affiliation>Koc Univ, Dept Biomed Sci &amp; Engn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yildiz, Erdost</creatorName>
      <givenName>Erdost</givenName>
      <familyName>Yildiz</familyName>
      <affiliation>Koc Univ, Res Ctr Translat Med, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Melikov, Rustamzhon</creatorName>
      <givenName>Rustamzhon</givenName>
      <familyName>Melikov</familyName>
      <affiliation>Koc Univ, Dept Elect &amp; Elect Engn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Srivastava, Shashi Bhushan</creatorName>
      <givenName>Shashi Bhushan</givenName>
      <familyName>Srivastava</familyName>
      <affiliation>Koc Univ, Dept Elect &amp; Elect Engn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Surme, Saliha</creatorName>
      <givenName>Saliha</givenName>
      <familyName>Surme</familyName>
      <affiliation>Koc Univ, Dept Mol Biol &amp; Genet, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Dogru, Itir Bakis</creatorName>
      <givenName>Itir Bakis</givenName>
      <familyName>Dogru</familyName>
      <affiliation>Koc Univ, Dept Biomed Sci &amp; Engn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Jalali, Houman Bahmani</creatorName>
      <givenName>Houman Bahmani</givenName>
      <familyName>Jalali</familyName>
      <affiliation>Koc Univ, Dept Biomed Sci &amp; Engn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ulgut, Burak</creatorName>
      <givenName>Burak</givenName>
      <familyName>Ulgut</familyName>
      <affiliation>Brikent Univ, Dept Chem, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sahin, Afsun</creatorName>
      <givenName>Afsun</givenName>
      <familyName>Sahin</familyName>
    </creator>
    <creator>
      <creatorName>Kavakli, Ibrahim Halil</creatorName>
      <givenName>Ibrahim Halil</givenName>
      <familyName>Kavakli</familyName>
      <affiliation>Koc Univ, Dept Mol Biol &amp; Genet, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Nizamoglu, Sedat</creatorName>
      <givenName>Sedat</givenName>
      <familyName>Nizamoglu</familyName>
    </creator>
  </creators>
  <titles>
    <title>Nanoengineering Inp Quantum Dot-Based Photoactive Biointerfaces For Optical Control Of Neurons</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/239512</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.3389/fnins.2021.652608</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Light-activated biointerfaces provide a non-genetic route for effective control of neural activity. InP quantum dots (QDs) have a high potential for such biomedical applications due to their uniquely tunable electronic properties, photostability, toxic-heavy-metal-free content, heterostructuring, and solution-processing ability. However, the effect of QD nanostructure and biointerface architecture on the photoelectrical cellular interfacing remained unexplored. Here, we unravel the control of the photoelectrical response of InP QD-based biointerfaces via nanoengineering from QD to device-level. At QD level, thin ZnS shell growth (similar to 0.65 nm) enhances the current level of biointerfaces over an order of magnitude with respect to only InP core QDs. At device-level, band alignment engineering allows for the bidirectional photoelectrochemical current generation, which enables light-induced temporally precise and rapidly reversible action potential generation and hyperpolarization on primary hippocampal neurons. Our findings show that nanoengineering QD-based biointerfaces hold great promise for next-generation neurostimulation devices.</description>
  </descriptions>
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