Yayınlanmış 1 Ocak 2021
| Sürüm v1
Dergi makalesi
Açık
Nanoengineering InP Quantum Dot-Based Photoactive Biointerfaces for Optical Control of Neurons
Oluşturanlar
- 1. Koc Univ, Dept Elect & Elect Engn, Istanbul, Turkey
- 2. Koc Univ, Dept Biomed Sci & Engn, Istanbul, Turkey
- 3. Koc Univ, Res Ctr Translat Med, Istanbul, Turkey
- 4. Koc Univ, Dept Mol Biol & Genet, Istanbul, Turkey
- 5. Brikent Univ, Dept Chem, Ankara, Turkey
Açıklama
Light-activated biointerfaces provide a non-genetic route for effective control of neural activity. InP quantum dots (QDs) have a high potential for such biomedical applications due to their uniquely tunable electronic properties, photostability, toxic-heavy-metal-free content, heterostructuring, and solution-processing ability. However, the effect of QD nanostructure and biointerface architecture on the photoelectrical cellular interfacing remained unexplored. Here, we unravel the control of the photoelectrical response of InP QD-based biointerfaces via nanoengineering from QD to device-level. At QD level, thin ZnS shell growth (similar to 0.65 nm) enhances the current level of biointerfaces over an order of magnitude with respect to only InP core QDs. At device-level, band alignment engineering allows for the bidirectional photoelectrochemical current generation, which enables light-induced temporally precise and rapidly reversible action potential generation and hyperpolarization on primary hippocampal neurons. Our findings show that nanoengineering QD-based biointerfaces hold great promise for next-generation neurostimulation devices.
Dosyalar
bib-918a7dd0-ed52-4063-bd75-1b8e1b6553de.txt
Dosyalar
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