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Nanoengineering InP Quantum Dot-Based Photoactive Biointerfaces for Optical Control of Neurons

Karatum, Onuralp; Aria, Mohammad Mohammadi; Eren, Guncem Ozgun; Yildiz, Erdost; Melikov, Rustamzhon; Srivastava, Shashi Bhushan; Surme, Saliha; Dogru, Itir Bakis; Jalali, Houman Bahmani; Ulgut, Burak; Sahin, Afsun; Kavakli, Ibrahim Halil; Nizamoglu, Sedat


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{
  "@context": "https://schema.org/", 
  "@id": 239512, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Koc Univ, Dept Elect & Elect Engn, Istanbul, Turkey", 
      "name": "Karatum, Onuralp"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Koc Univ, Dept Biomed Sci & Engn, Istanbul, Turkey", 
      "name": "Aria, Mohammad Mohammadi"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Koc Univ, Dept Biomed Sci & Engn, Istanbul, Turkey", 
      "name": "Eren, Guncem Ozgun"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Koc Univ, Res Ctr Translat Med, Istanbul, Turkey", 
      "name": "Yildiz, Erdost"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Koc Univ, Dept Elect & Elect Engn, Istanbul, Turkey", 
      "name": "Melikov, Rustamzhon"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Koc Univ, Dept Elect & Elect Engn, Istanbul, Turkey", 
      "name": "Srivastava, Shashi Bhushan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Koc Univ, Dept Mol Biol & Genet, Istanbul, Turkey", 
      "name": "Surme, Saliha"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Koc Univ, Dept Biomed Sci & Engn, Istanbul, Turkey", 
      "name": "Dogru, Itir Bakis"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Koc Univ, Dept Biomed Sci & Engn, Istanbul, Turkey", 
      "name": "Jalali, Houman Bahmani"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Brikent Univ, Dept Chem, Ankara, Turkey", 
      "name": "Ulgut, Burak"
    }, 
    {
      "@type": "Person", 
      "name": "Sahin, Afsun"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Koc Univ, Dept Mol Biol & Genet, Istanbul, Turkey", 
      "name": "Kavakli, Ibrahim Halil"
    }, 
    {
      "@type": "Person", 
      "name": "Nizamoglu, Sedat"
    }
  ], 
  "datePublished": "2021-01-01", 
  "description": "Light-activated biointerfaces provide a non-genetic route for effective control of neural activity. InP quantum dots (QDs) have a high potential for such biomedical applications due to their uniquely tunable electronic properties, photostability, toxic-heavy-metal-free content, heterostructuring, and solution-processing ability. However, the effect of QD nanostructure and biointerface architecture on the photoelectrical cellular interfacing remained unexplored. Here, we unravel the control of the photoelectrical response of InP QD-based biointerfaces via nanoengineering from QD to device-level. At QD level, thin ZnS shell growth (similar to 0.65 nm) enhances the current level of biointerfaces over an order of magnitude with respect to only InP core QDs. At device-level, band alignment engineering allows for the bidirectional photoelectrochemical current generation, which enables light-induced temporally precise and rapidly reversible action potential generation and hyperpolarization on primary hippocampal neurons. Our findings show that nanoengineering QD-based biointerfaces hold great promise for next-generation neurostimulation devices.", 
  "headline": "Nanoengineering InP Quantum Dot-Based Photoactive Biointerfaces for Optical Control of Neurons", 
  "identifier": 239512, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Nanoengineering InP Quantum Dot-Based Photoactive Biointerfaces for Optical Control of Neurons", 
  "url": "https://aperta.ulakbim.gov.tr/record/239512"
}
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