1 Ocak 2021 Dergi makalesi Açık Erişim

Duyar, Halil; Portakal, Huseyin S.; Yalcin, Ergin; Kanat, Beyza; Doluca, Osman; Seferoglu, Zeynel

Dublin Core

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  <dc:creator>Duyar, Halil</dc:creator>
  <dc:creator>Portakal, Huseyin S.</dc:creator>
  <dc:creator>Yalcin, Ergin</dc:creator>
  <dc:creator>Kanat, Beyza</dc:creator>
  <dc:creator>Doluca, Osman</dc:creator>
  <dc:creator>Seferoglu, Zeynel</dc:creator>
  <dc:date>2021-01-01</dc:date>
  <dc:description>The development of fluorescent dyes capable of selective recognition of G-quadruplexes is essential for studying its localization and biological functions. However, considering the G-quadruplex topologies may vary significantly, the synthesis of compounds showing both selectivity and strong fluorescence properties still remains a great challenge. Recently we have developed fluorene/fluorenone derivatives with structure-specific binding towards dsRNA, indicating its potential for structure-selective ligands. Herein, we report the synthesis of novel fluorene/fluorenone derivatives and their selectivity towards various DNA structures, particularly G-quadruplexes, two of which showed strong affinity to the proto-oncogene c-myc promoter G-quadruplex.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/237424</dc:identifier>
  <dc:identifier>oai:aperta.ulakbim.gov.tr:237424</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>BIOORGANIC &amp; MEDICINAL CHEMISTRY LETTERS 36</dc:source>
  <dc:title>Fluorene/fluorenone carboxamide derivatives as selective light-up fluorophores for c-myc G-quadruplex</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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